Tylenol w/ codeine and Sonata drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tylenol w/ codeine (acetaminophen; codeine phosphate) and Sonata (zaleplon). Common drug interactions include neck pain among females and fracture among males.

The phase IV clinical study analyzes what interactions people have when they take Tylenol w/ codeine and Sonata. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Tylenol w/ codeine?

Tylenol w/ codeine has active ingredients of acetaminophen; codeine phosphate. It is often used in pain. eHealthMe is studying from 8,107 Tylenol w/ codeine users. Check the latest studies of Tylenol w/ codeine.

What is Sonata?

Sonata has active ingredients of zaleplon. It is often used in insomnia. eHealthMe is studying from 3,330 Sonata users. Check the latest studies of Sonata.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

13 people who take Tylenol w/ codeine and Sonata together, and have interactions are studied.

Tylenol w/ codeine and Sonata drug interactions.

What are the common drug interactions of Tylenol W/ Codeine and Sonata, by gender? *:

female:

Neck pain
Nervousness
Oedema peripheral (superficial swelling)
Oropharyngeal pain
Orthopnoea (shortness of breath (dyspnea) when lying down)
Fall
Agitation (state of anxiety or nervous excitement)
Arthralgia (joint pain)
Lower limb fracture
Palpitations (feelings or sensations that your heart is pounding or racing)

male:

Fracture
Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder)
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Tremor (trembling or shaking movements in one or more parts of your body)
Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Cardiac disorder
Completed suicide (act of taking one's own life)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Skin cancer
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)

What are the common drug interactions of Tylenol W/ Codeine and Sonata, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Cardiac disorder
Migraine (headache)
Type 1 diabetes mellitus

30-39:

n/a

40-49:

Tendon disorder (disease of tendon)
Cardiac disorder
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Fracture
Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder)
Chondromalacia (anterior knee pain due to irritation of the cartilage on the under surface of the kneecap)
Congestive cardiomyopathy (weakening of heart muscle)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Syncope (loss of consciousness with an inability to maintain postural tone)
Synovitis (inflammation of the synovial membrane)

50-59:

Agitation (state of anxiety or nervous excitement)
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Blood glucose increased
Confusional state
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Somnolence (a state of near-sleep, a strong desire for sleep)

60+:

Fall
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Anxiety
Aortic dilatation
Aortic valve incompetence
Apallic syndrome (serious brain damage, when cortical parts of the brain are disconnected from brainstem)
Arrhythmia (irregular heartbeat)
Arrhythmia supraventricular (irregular heartbeat supraventricular origin)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 2 people, 15.38%
Sleep Disorder: 1 person, 7.69%
Post-Traumatic Stress Disorder: 1 person, 7.69%
Metastases To Bone (cancer spreads to bone): 1 person, 7.69%
Insulin-Requiring Type 2 Diabetes Mellitus: 1 person, 7.69%
Heart Rate Irregular: 1 person, 7.69%
Depression: 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

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