Tylenol w/ codeine and Zelnorm drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tylenol w/ codeine (acetaminophen; codeine phosphate) and Zelnorm (tegaserod maleate). Common drug interactions include coronary artery disease among females and abdominal discomfort among males.

The phase IV clinical study analyzes what interactions people have when they take Tylenol w/ codeine and Zelnorm. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Tylenol w/ codeine?

Tylenol w/ codeine has active ingredients of acetaminophen; codeine phosphate. It is often used in pain. eHealthMe is studying from 8,107 Tylenol w/ codeine users. Check the latest studies of Tylenol w/ codeine.

What is Zelnorm?

Zelnorm has active ingredients of tegaserod maleate. eHealthMe is studying from 7,261 Zelnorm users. Check the latest studies of Zelnorm.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 15, 2026

11 people who take Tylenol w/ codeine and Zelnorm together, and have interactions are studied.

Tylenol w/ codeine and Zelnorm drug interactions.

What are the common drug interactions of Tylenol W/ Codeine and Zelnorm, by gender? *:

female:

Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Cough
Dehydration (dryness resulting from the removal of water)
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Dizziness
Dyspnoea (difficult or laboured respiration)
General physical health deterioration (weak health status)
Haematoma (collection of blood outside the blood vessels)
Hepatic steatosis (fatty liver disease)
Hypercalcaemia (elevated calcium (ca+) level in the blood)

male:

Abdominal discomfort
Actinomyces test positive
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Cerebellar infarction (impaired blood circulation to cerebellum)
Cerebellar syndrome (impaired blood circulation to cerebellum due to lesion in artery)
Cerebral artery stenosis (hardening of brain blood vessels)
Cerebral ventricle dilatation (enlargement of ventricle of brain)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Clumsiness (a lack of coordination or elegance)
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)

What are the common drug interactions of Tylenol W/ Codeine and Zelnorm, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Cardiac disorder
Migraine (headache)
Type 1 diabetes mellitus

30-39:

n/a

40-49:

Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Hyperglycaemia (high blood sugar)

50-59:

Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Productive cough
Pulmonary hypertension (increase in blood pressure in the lung artery)
Restless legs syndrome (a powerful urge to move your legs)
Rhinitis allergic (inflammation of the nasal airways due to allergy)
Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Spinal osteoarthritis (joint cartilage loss in spine)
Stent placement
Tachycardia (a heart rate that exceeds the range of 100 beats/min)

60+:

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Diabetic nephropathy (diabetic kidney disease)
Confusional state
Cough
Dehydration (dryness resulting from the removal of water)
Fatigue (feeling of tiredness)
Hypercalcaemia (elevated calcium (ca+) level in the blood)
Hypersomnia (excessive daytime sleepiness (eds))
Sleep disorder
Diplopia (double vision)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 45.45%
High Blood Cholesterol: 4 people, 36.36%
High Blood Pressure: 4 people, 36.36%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 4 people, 36.36%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 4 people, 36.36%
Cardiac Failure Congestive: 3 people, 27.27%
Constipation: 3 people, 27.27%
Diabetes: 3 people, 27.27%
Glaucoma (increased fluid pressure in the eye with vision loss): 3 people, 27.27%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 3 people, 27.27%

* Approximation only. Some reports may have incomplete information.

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