Tylenol and Aczone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tylenol (acetaminophen) and Aczone (dapsone). Common drug interactions include disability among females and general physical health deterioration among males.

The phase IV clinical study analyzes what interactions people have when they take Tylenol and Aczone. It is created by eHealthMe based on reports of 40 people who take the same drugs from the FDA, and is updated regularly.

What is Tylenol?

Tylenol has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 222,310 Tylenol users. Check the latest studies of Tylenol.

What is Aczone?

Aczone has active ingredients of dapsone. It is often used in acne. eHealthMe is studying from 1,152 Aczone users. Check the latest studies of Aczone.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

40 people who take Tylenol and Aczone together, and have interactions are studied.

What are the common drug interactions of Tylenol and Aczone, by gender? *:

female:

Disability
Discomfort
Dry mouth
Dysgeusia (disorder of the sense of taste)
Ectopic pregnancy (a pregnancy in which the foetus develops outside the uterus, typically in a fallopian tube)
Fatigue (feeling of tiredness)
Gait disturbance
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Haemochromatosis (body to absorb more iron than usual from food)
Hypoaesthesia (reduced sense of touch or sensation)

male:

General physical health deterioration (weak health status)
Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
Depressed mood
Irritability
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Mood swings (an extreme or rapid change in mood)
White blood cell count decreased
Abdominal pain
Balance disorder
Central obesity (belly fat)

What are the common drug interactions of Tylenol and Aczone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

General physical health deterioration (weak health status)
Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
Anxiety
Depressed mood
Irritability
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Mood swings (an extreme or rapid change in mood)
Vomiting

30-39:

Abdominal discomfort
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Infusion site extravasation (flow of (blood or lymph) from infusion site)
Infusion site haemorrhage (bleeding from infusion site)
Irritable bowel syndrome
Liver disorder (liver diseases)
Nausea (feeling of having an urge to vomit)
Ovarian cyst (fluid filled sac of the ovary)

40-49:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Pulmonary embolism (blockage of the main artery of the lung)

50-59:

Blood glucose increased
Blood magnesium increased
Blood urea increased
Gait disturbance
Hypoaesthesia (reduced sense of touch or sensation)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Abdominal pain
Balance disorder
Central obesity (belly fat)
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)

60+:

Acute respiratory failure
Arterial insufficiency (lack of enough blood flow through the arteries)
Interstitial lung disease
Lung disorder (lung disease)
Protein urine present
Prothrombin level increased
Troponin increased
White blood cell count decreased
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blood creatinine increased

What are the existing conditions these people have? *

Hypertonic Bladder (bladder-storage function that causes a sudden urge to urinate): 9 people, 22.50%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 22.50%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 17.50%
Stress And Anxiety: 5 people, 12.50%
Depression: 5 people, 12.50%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 5 people, 12.50%
Urinary Tract Infection: 2 people, 5.00%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 2 people, 5.00%
Immunodeficiency Disorders: 2 people, 5.00%
Hypersensitivity: 2 people, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Tylenol and Aczone?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously