Tylenol and Cobalamin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tylenol (acetaminophen) and Cobalamin (vitamin b12). Common drug interactions include frequent bowel movements among females and blood pressure systolic increased among males.

The phase IV clinical study analyzes what interactions people have when they take Tylenol and Cobalamin. It is created by eHealthMe based on reports of 73 people who take the same drugs from the FDA, and is updated regularly.

What is Tylenol?

Tylenol has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 222,310 Tylenol users. Check the latest studies of Tylenol.

What is Cobalamin?

Cobalamin has active ingredients of vitamin b12. eHealthMe is studying from 3,429 Cobalamin users. Check the latest studies of Cobalamin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

73 people who take Tylenol and Cobalamin together, and have interactions are studied.

Tylenol and Cobalamin drug interactions.

What are the common drug interactions of Tylenol and Cobalamin, by gender? *:

female:

Frequent bowel movements
Hepatic enzyme increased
Ocular toxicity (damages eye)
Rash pruritic (redness with itching)
Tendonitis (a condition that causes pain and swelling of tendons)
Alopecia (absence of hair from areas of the body)
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Insomnia (sleeplessness)
Neck pain

male:

Blood pressure systolic increased
Asthenia (weakness)
Decreased appetite
Depression
Diarrhoea
Dizziness
Drug ineffective
Dry eye (lack of adequate tears)
Dry mouth
Dry throat

What are the common drug interactions of Tylenol and Cobalamin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal pain upper
Arthralgia (joint pain)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Confusional state
Constipation
Depression
Disturbance in attention
Drug ineffective
Dry throat
Dyskinesia (abnormality or impairment of voluntary movement)

40-49:

Arthritis infective (purulent invasion of a joint by an infectious agent which produces arthritis)
Blood pressure increased
Blood pressure systolic increased
Cellulitis (infection under the skin)
Device dislocation
Drug hypersensitivity
Drug ineffective
Fall
Fluid retention (an abnormal accumulation of fluid in the blood)
Foot fracture

50-59:

Abdominal discomfort
Alopecia (absence of hair from areas of the body)
Arthralgia (joint pain)
C-reactive protein increased
Chest pain
Disease recurrence
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Impaired work ability

60+:

Blood pressure systolic increased
Drug intolerance (drug sensitivity)
Uveitis (inflammation of the uvea)
Anxiety
Asthenia (weakness)
Back pain
Fatigue (feeling of tiredness)
Intervertebral disc degeneration (spinal disc degeneration)
Arthralgia (joint pain)
Decreased appetite

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 26 people, 35.62%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 7 people, 9.59%
Constipation: 5 people, 6.85%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 4 people, 5.48%
Helicobacter Infection (helicobacter pylori (h. pylori) infects stomach): 4 people, 5.48%

* Approximation only. Some reports may have incomplete information.

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