Tylenol and Palynziq drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tylenol (acetaminophen) and Palynziq (pegvaliase-pqpz). Common drug interactions include urticaria among females and arthralgia among males.

The phase IV clinical study analyzes what interactions people have when they take Tylenol and Palynziq. It is created by eHealthMe based on reports of 56 people who take the same drugs from the FDA, and is updated regularly.

What is Tylenol?

Tylenol has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 222,309 Tylenol users. Check the latest studies of Tylenol.

What is Palynziq?

Palynziq has active ingredients of pegvaliase-pqpz. eHealthMe is studying from 6,071 Palynziq users. Check the latest studies of Palynziq.

On Jul, 19, 2026

56 people who take Tylenol and Palynziq together, and have interactions are studied.

What are the common drug interactions of Tylenol and Palynziq, by gender? *:

female:

Urticaria (rash of round, red welts on the skin that itch intensely)
Injection site reaction
Hypersensitivity
Dyspnoea (difficult or laboured respiration)
Feeling hot
Pain in extremity
Pruritus (severe itching of the skin)
Wheezing (a high-pitched whistling sound made while you breath)
Arthralgia (joint pain)
Head injury

male:

Arthralgia (joint pain)
Erythema (redness of the skin)
Dizziness
Injection site erythema (redness at injection site)
Injection site swelling
Pharyngeal disorder
Vomiting
Weight decreased
Groin pain
Decreased appetite

What are the common drug interactions of Tylenol and Palynziq, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Contusion (a type of hematoma of tissue in which capillaries)
Diarrhoea
Dizziness
Hypersensitivity
Injection site reaction
Rash
Urticaria (rash of round, red welts on the skin that itch intensely)
Injection site erythema (redness at injection site)
Injection site swelling

20-29:

Arthralgia (joint pain)
Erythema (redness of the skin)
Groin pain
Gait disturbance
Dizziness
Pharyngeal disorder

30-39:

Arthralgia (joint pain)
Pain in extremity
Head injury
Injection site bruising
Asthenia (weakness)
Epistaxis (bleed from the nose)
Erythema (redness of the skin)
Feeling hot
Gait disturbance
Haematemesis (vomiting of blood)

40-49:

Chest discomfort
Feeling hot
Hyperhidrosis (abnormally increased sweating)
Hypersensitivity
Injection site erythema (redness at injection site)
Injection site pruritus (severe itching at injection site)
Injection site reaction
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Dyspnoea (difficult or laboured respiration)
Pruritus (severe itching of the skin)

50-59:

Injection site pain
Amino acid level decreased
Amino acid level increased
Fibula fracture

60+:

n/a

* Approximation only. Some reports may have incomplete information.

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