Tyr and Melatonin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tyr (tyrosine) and Melatonin (melatonin). Common drug interactions include emotional disorder among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Tyr and Melatonin. It is created by eHealthMe based on reports of 54 people who take the same drugs from the FDA, and is updated regularly.

What is Tyr?

Tyr has active ingredients of tyrosine. eHealthMe is studying from 840 Tyr users. Check the latest studies of Tyr.

What is Melatonin?

Melatonin has active ingredients of melatonin. It is often used in insomnia. eHealthMe is studying from 56,212 Melatonin users. Check the latest studies of Melatonin.

On Jul, 12, 2026

54 people who take Tyr and Melatonin together, and have interactions are studied.

What are the common drug interactions of Tyr and Melatonin, by gender? *:

female:

Emotional disorder
Food craving
Muscle spasms (muscle contraction)
Nervousness
Tooth disorder (tooth disease)
Weight increased
Abdominal distension
Abnormal dreams
Affect lability (emotional incontinence)
Asthenia (weakness)

male:

Fatigue (feeling of tiredness)
Depression
Abdominal distension
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Constipation
Decreased appetite
Drug intolerance (drug sensitivity)
Food allergy
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Hangover

What are the common drug interactions of Tyr and Melatonin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Depression
Abdominal pain
Agitation (state of anxiety or nervous excitement)
Diarrhoea
Dizziness
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Faeces discoloured
Headache (pain in head)
Malabsorption (a state arising from abnormality in absorption of food nutrients across the gastrointestinal (gi) tract)
Rash

20-29:

Lip swelling
Loss of libido (loss of sexual urge)
Ocular hyperaemia (an abnormally large amount of blood in eye)
Pain
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Renal pain (kidney pain)
Vision blurred
Asthenia (weakness)
Abdominal discomfort
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)

30-39:

Abdominal distension
Anxiety
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Constipation
Decreased appetite
Drug intolerance (drug sensitivity)
Fatigue (feeling of tiredness)
Flatulence (flatus expelled through the anus)
Food allergy
Gastrointestinal disorder (functional problems of gastrointestinal tract)

40-49:

Affect lability (emotional incontinence)
Kidney infection
Nephrolithiasis (calculi in the kidneys)
Visual impairment

50-59:

Depression
Overdose
Suicide attempt
Abnormal sensation in eye
Chest pain
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Hangover
Heart rate increased
Muscle spasms (muscle contraction)
Swelling

60+:

Sinusitis (inflammation of sinus)
Systemic mycosis (fungal infections of the body)
Cardiac disorder
Cataract (clouding of the lens inside the eye)
Coma (state of unconsciousness lasting more than six hours)
Depressed level of consciousness
Drug effect increased
Drug ineffective
Drug level decreased
Dry eye (lack of adequate tears)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 17 people, 31.48%
Immunodeficiency Common Variable: 11 people, 20.37%
Sleep Disorder: 8 people, 14.81%
High Blood Pressure: 6 people, 11.11%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 11.11%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 5 people, 9.26%
Type 2 Diabetes: 4 people, 7.41%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 4 people, 7.41%
Hyperlipidaemia (presence of excess lipids in the blood): 4 people, 7.41%
Asthma Exercise Induced: 4 people, 7.41%

* Approximation only. Some reports may have incomplete information.

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