Tysabri and Methylin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tysabri (natalizumab) and Methylin (methylphenidate hydrochloride). Common drug interactions include blood pressure increased among females and encephalitis viral among males.

The phase IV clinical study analyzes what interactions people have when they take Tysabri and Methylin. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Tysabri?

Tysabri has active ingredients of natalizumab. It is often used in multiple sclerosis. eHealthMe is studying from 221,369 Tysabri users. Check the latest studies of Tysabri.

What is Methylin?

Methylin has active ingredients of methylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 1,116 Methylin users. Check the latest studies of Methylin.

On Aug, 04, 2026

11 people who take Tysabri and Methylin together, and have interactions are studied.

What are the common drug interactions of Tysabri and Methylin, by gender? *:

female:

Blood pressure increased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Stress
Tremor (trembling or shaking movements in one or more parts of your body)
Weight decreased
Pancreatitis acute (sudden inflammation of pancreas)

male:

Encephalitis viral (inflammation of the brain due to viral infection)
Muscle spasms (muscle contraction)
Memory impairment
Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Muscle twitching
Muscular weakness (muscle weakness)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Pneumonia
Progressive multifocal leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells)

What are the common drug interactions of Tysabri and Methylin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Jc virus infection
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Muscle twitching
Muscular weakness (muscle weakness)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Pneumonia
Progressive multifocal leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells)
Pyrexia (fever)
Renal cancer metastatic (cancer of kidney spreads to other part)
Transitional cell carcinoma (cancer tumour inner most layer of urinary system)

50-59:

Blood pressure increased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Stress
Tremor (trembling or shaking movements in one or more parts of your body)
Weight decreased

60+:

n/a

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 27.27%
Drowsiness: 3 people, 27.27%
Sleep Disorder: 1 person, 9.09%
Pain: 1 person, 9.09%
Neurogenic Bladder (the normal function of the bladder is to store and empty urine in a coordinated, controlled fashion): 1 person, 9.09%
Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 1 person, 9.09%
Gait Disturbance: 1 person, 9.09%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 1 person, 9.09%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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