Tysabri and Metronidazole drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tysabri (natalizumab) and Metronidazole (metronidazole). Common drug interactions include crohn's disease among females and colon cancer metastatic among males.

The phase IV clinical study analyzes what interactions people have when they take Tysabri and Metronidazole. It is created by eHealthMe based on reports of 97 people who take the same drugs from the FDA, and is updated regularly.

What is Tysabri?

Tysabri has active ingredients of natalizumab. It is often used in multiple sclerosis. eHealthMe is studying from 221,369 Tysabri users. Check the latest studies of Tysabri.

What is Metronidazole?

Metronidazole has active ingredients of metronidazole. It is often used in vaginitis bacterial. eHealthMe is studying from 59,578 Metronidazole users. Check the latest studies of Metronidazole.

On Aug, 05, 2026

97 people who take Tysabri and Metronidazole together, and have interactions are studied.

Tysabri and Metronidazole drug interactions.

What are the common drug interactions of Tysabri and Metronidazole, by gender? *:

female:

Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Anaemia (lack of blood)
Dyspnoea (difficult or laboured respiration)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pneumonia bacterial (pneumonia associated with bacterial infection)
Urosepsis (secondary infection that occurs when a urinary tract infection spreads to the bloodstream)
Facial paresis (weakness in facial muscle movement)
Viral infection
Anxiety
Back pain

male:

Colon cancer metastatic (cancer of colon spreads to other part of body)
General physical health deterioration (weak health status)
Hypersomnia (excessive daytime sleepiness (eds))
Hypertension (high blood pressure)
Memory impairment
Myalgia (muscle pain)
Anxiety
Asthenia (weakness)
Femoral neck fracture (neck of femur bone fracture)
Infusion related reaction

What are the common drug interactions of Tysabri and Metronidazole, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Colon cancer

20-29:

Asthenia (weakness)
Back pain
Feeling hot
Gait disturbance
Myoclonus (a brief, involuntary twitching of a muscle or a group of muscles)
Myopia (difficult to see objects that are far away)
Neck pain
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Seizure like phenomena (a variety of medical conditions may produce sudden episodes which have some similarities to epileptic seizures)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)

30-39:

Progressive multifocal leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Fatigue (feeling of tiredness)
Decreased immune responsiveness
Colon cancer metastatic (cancer of colon spreads to other part of body)
Abdominal pain
Anaemia (lack of blood)
Dyspnoea (difficult or laboured respiration)
Pneumonia bacterial (pneumonia associated with bacterial infection)
Urosepsis (secondary infection that occurs when a urinary tract infection spreads to the bloodstream)

40-49:

Muscular weakness (muscle weakness)
Nausea (feeling of having an urge to vomit)
Abscess (pus)
Bladder injury
Cellulitis (infection under the skin)
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Cystocele (a condition that occurs when the tough fibrous wall between a woman's bladder and her vagina is torn by childbirth)
Drug intolerance (drug sensitivity)
Dysfunctional uterine bleeding
Dysmenorrhoea (painful menstruation)

50-59:

Dehydration (dryness resulting from the removal of water)
Dizziness
Gait disturbance
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Hepatitis acute
Hypoglycaemia (deficiency of glucose in the bloodstream)
Hypokalaemia (low potassium)
Idiosyncratic drug reaction (unusual effect of the medication)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Musculoskeletal disorder (disease of the body's muscles, joints, tendons, ligaments and nerves)

60+:

Hypertension (high blood pressure)
Depression
Chorea (abnormal involuntary movement disorder)
Fatigue (feeling of tiredness)
Femoral neck fracture (neck of femur bone fracture)
Gait disturbance
Infusion related reaction
Metabolic encephalopathy (disorder or disease of the brain due to the body's disability to use energy)
Pruritus (severe itching of the skin)
Urinary tract infection

What are the existing conditions these people have? *

Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 10 people, 10.31%
Pain: 8 people, 8.25%
Gait Disturbance: 7 people, 7.22%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 6 people, 6.19%
Stress And Anxiety: 5 people, 5.15%
Nausea (feeling of having an urge to vomit): 5 people, 5.15%
Indigestion: 5 people, 5.15%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 5.15%

* Approximation only. Some reports may have incomplete information.

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