Uloric and Solu-cortef drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Uloric (febuxostat) and Solu-cortef (hydrocortisone sodium succinate). Common drug interactions include abdominal pain upper among females and infusion related reaction among males.

The phase IV clinical study analyzes what interactions people have when they take Uloric and Solu-cortef. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Uloric?

Uloric has active ingredients of febuxostat. It is often used in gout. eHealthMe is studying from 8,067 Uloric users. Check the latest studies of Uloric.

What is Solu-cortef?

Solu-cortef has active ingredients of hydrocortisone sodium succinate. eHealthMe is studying from 7,983 Solu-cortef users. Check the latest studies of Solu-cortef.



On Jul, 11, 2026

15 people who take Uloric and Solu-cortef together, and have interactions are studied.

Uloric and Solu-cortef drug interactions.

What are the common drug interactions of Uloric and Solu-Cortef, by gender? *:

female:

  1. Abdominal pain upper
  2. Ear infection
  3. Food poisoning (poison in food)
  4. Gastric infection (infection of stomach)
  5. Infusion site pain
  6. Kidney infection
  7. Urinary tract infection
  8. Weight increased
  9. Infusion site haemorrhage (bleeding from infusion site)
  10. Infusion site mass

male:

  1. Infusion related reaction
  2. Therapeutic response decreased (less preventive response)
  3. Blood potassium decreased
  4. Blood urea increased
  5. Chills (felling of cold)
  6. Decreased appetite
  7. Diarrhoea
  8. Drug ineffective
  9. Hypotension (abnormally low blood pressure)
  10. Ill-defined disorder

What are the common drug interactions of Uloric and Solu-Cortef, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Therapeutic response decreased (less preventive response)
  2. Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
  3. Infusion related reaction

40-49:

  1. Drug ineffective
  2. Urticaria (rash of round, red welts on the skin that itch intensely)

50-59:

  1. Infusion related reaction

60+:

  1. Dehydration (dryness resulting from the removal of water)
  2. Pyrexia (fever)
  3. Chills (felling of cold)
  4. Decreased appetite
  5. Diarrhoea
  6. Hypotension (abnormally low blood pressure)
  7. Ill-defined disorder
  8. Joint swelling
  9. Pain
  10. Rash generalised (rash on most of body parts)

What are the existing conditions these people have? *

  1. Gouty Tophus (a deposit of urates in the skin and tissue around a joint or in the external ear): 4 people, 26.67%
  2. Immunodeficiency Common Variable: 4 people, 26.67%
  3. High Blood Cholesterol: 3 people, 20.00%
  4. Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 2 people, 13.33%
  5. Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 2 people, 13.33%
  6. Constipation: 2 people, 13.33%
  7. Coronary Heart Disease (narrowing or blockage of the coronary arteries): 2 people, 13.33%
  8. Diarrhea: 2 people, 13.33%
  9. Heart Attack: 2 people, 13.33%
  10. Cardiac Failure Congestive: 2 people, 13.33%

* Approximation only. Some reports may have incomplete information.

Do you take Uloric and Solu-cortef?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Uloric and Solu-cortef:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Uloric:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Solu-cortef:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Uloric and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Solu-cortef and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on febuxostat and hydrocortisone sodium succinate (the active ingredients of Uloric and Solu-cortef, respectively), and Uloric and Solu-cortef (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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