Ultracet and Actonel drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ultracet (acetaminophen; tramadol hydrochloride) and Actonel (risedronate sodium). Common drug interactions include malaise among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Ultracet and Actonel. It is created by eHealthMe based on reports of 97 people who take the same drugs from the FDA, and is updated regularly.

What is Ultracet?

Ultracet has active ingredients of acetaminophen; tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 6,351 Ultracet users. Check the latest studies of Ultracet.

What is Actonel?

Actonel has active ingredients of risedronate sodium. It is often used in osteoporosis. eHealthMe is studying from 29,369 Actonel users. Check the latest studies of Actonel.

On Jul, 19, 2026

97 people who take Ultracet and Actonel together, and have interactions are studied.

What are the common drug interactions of Ultracet and Actonel, by gender? *:

female:

Malaise (a feeling of general discomfort or uneasiness)
Swelling
Formication (a sensation that exactly resembles that of small insects crawling on (or under) the skin)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Oropharyngeal pain
Pruritus (severe itching of the skin)
Lower limb fracture
Mobility decreased (ability to move is reduced)
Skin exfoliation (removal of the oldest dead skin cells)
Weight increased

male:

Anxiety
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Hypercholesterolaemia (high levels of cholesterol in the blood)
Injury
Nausea (feeling of having an urge to vomit)
Nephrolithiasis (calculi in the kidneys)
Peptic ulcer
Tooth fracture
Abdominal pain lower
Arthropathy

What are the common drug interactions of Ultracet and Actonel, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anxiety
Anxiety disorder
Bone loss
Bone pain
Complex regional pain syndrome (long lasting pain condition most often affecting one of the limbs (arms, legs, hands, or feet))
Hypovitaminosis (any of several diseases caused by deficiency of one or more vitamins)
Joint dislocation (a joint position is changed from normal position)
Lower limb fracture
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Pulmonary embolism (blockage of the main artery of the lung)

40-49:

Avulsion fracture (bone fracture)
Chest pain
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hallucination, auditory (perceiving sounds without auditory stimulus)
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Myositis (inflammation of the muscles)
Peripheral sensory neuropathy (damage to one or more of your peripheral nerves)
Pneumonia
Polyp colorectal

50-59:

Nausea (feeling of having an urge to vomit)
Abdominal pain
Diarrhoea
Dry mouth
Fatigue (feeling of tiredness)
Formication (a sensation that exactly resembles that of small insects crawling on (or under) the skin)
Headache (pain in head)
Lower limb fracture
Medical device complication
Mobility decreased (ability to move is reduced)

60+:

Vomiting
Dyspnoea (difficult or laboured respiration)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Dehydration (dryness resulting from the removal of water)
Gastric ulcer (stomach ulcer)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hypotension (abnormally low blood pressure)
Nephrolithiasis (calculi in the kidneys)
Peptic ulcer
Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder)

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 25 people, 25.77%
High Blood Pressure: 9 people, 9.28%
High Blood Cholesterol: 9 people, 9.28%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 8.25%
Hypersensitivity: 6 people, 6.19%
Blood Pressure Abnormal: 6 people, 6.19%
Asthma: 6 people, 6.19%
Insomnia (sleeplessness): 5 people, 5.15%
Muscle Spasms (muscle contraction): 5 people, 5.15%
Heart Rate Irregular: 5 people, 5.15%

* Approximation only. Some reports may have incomplete information.

Do you take Ultracet and Actonel?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously