Ultracet and Azelastine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ultracet (acetaminophen; tramadol hydrochloride) and Azelastine (azelastine hydrochloride). Common drug interactions include drug ineffective among females and constipation among males.

The phase IV clinical study analyzes what interactions people have when they take Ultracet and Azelastine. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Ultracet?

Ultracet has active ingredients of acetaminophen; tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 6,351 Ultracet users. Check the latest studies of Ultracet.

What is Azelastine?

Azelastine has active ingredients of azelastine hydrochloride. It is often used in allergies. eHealthMe is studying from 17,400 Azelastine users. Check the latest studies of Azelastine.



On Jul, 11, 2026

15 people who take Ultracet and Azelastine together, and have interactions are studied.

Ultracet and Azelastine drug interactions.

What are the common drug interactions of Ultracet and Azelastine, by gender? *:

female:

  1. Drug ineffective
  2. Asthma
  3. Chest discomfort
  4. Conversion disorder (neurological symptoms, such as numbness, blindness, paralysis, or fits without a definable organic cause)
  5. Dizziness
  6. Gingivitis (inflammation of gums)
  7. Headache (pain in head)
  8. Heart rate increased
  9. Nephrolithiasis (calculi in the kidneys)
  10. Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)

male:

  1. Constipation
  2. Diarrhoea
  3. Erythema (redness of the skin)
  4. Fatigue (feeling of tiredness)
  5. Pneumonia
  6. Arthralgia (joint pain)
  7. Asthenia (weakness)
  8. Blood pressure increased
  9. Capillary disorder (capillary disease)
  10. Chills (felling of cold)

What are the common drug interactions of Ultracet and Azelastine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Chest discomfort
  2. Conversion disorder (neurological symptoms, such as numbness, blindness, paralysis, or fits without a definable organic cause)
  3. Dizziness
  4. Drug ineffective
  5. Headache (pain in head)
  6. Heart rate increased
  7. Motion sickness (travel sickness)
  8. Nephrolithiasis (calculi in the kidneys)
  9. Nervous system disorder (a general class of medical conditions affecting the nervous system)
  10. Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)

50-59:

  1. Arthralgia (joint pain)
  2. Asthenia (weakness)
  3. Blood pressure increased
  4. Capillary disorder (capillary disease)
  5. Chills (felling of cold)
  6. Constipation
  7. Diarrhoea
  8. Disease progression
  9. Dry skin
  10. Dyspnoea exertional (breathlessness or shortness of breath)

60+:

  1. Constipation
  2. Diarrhoea
  3. Pneumonia
  4. Dizziness
  5. Drug administration error
  6. Dyspnoea (difficult or laboured respiration)
  7. Erythema (redness of the skin)
  8. Fatigue (feeling of tiredness)
  9. Full blood count decreased
  10. Pruritus (severe itching of the skin)

What are the existing conditions these people have? *

  1. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 26.67%
  2. Urination - Painful: 3 people, 20.00%
  3. Asthma: 3 people, 20.00%
  4. Constipation: 3 people, 20.00%
  5. Cough: 3 people, 20.00%
  6. Enterocolitis (inflammation of the digestive tract, involving enteritis of the small intestine and colitis of the colon): 3 people, 20.00%
  7. Small Cell Lung Cancer Extensive Stage (small cell lung cancer that has spread (metastasized) to other regions of the body such as another lobe of the lung or the brain): 3 people, 20.00%
  8. High Blood Pressure: 3 people, 20.00%
  9. Hypersensitivity: 3 people, 20.00%
  10. High Blood Cholesterol: 3 people, 20.00%

* Approximation only. Some reports may have incomplete information.

Do you take Ultracet and Azelastine?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously



Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Ultracet and Azelastine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Ultracet:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Azelastine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Ultracet and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Azelastine and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; tramadol hydrochloride and azelastine hydrochloride (the active ingredients of Ultracet and Azelastine, respectively), and Ultracet and Azelastine (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



Recent studies on eHealthMe: