Unisom and Tylenol w/ codeine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Unisom (doxylamine succinate) and Tylenol w/ codeine (acetaminophen; codeine phosphate). Common drug interactions include drug exposure during pregnancy among females and coronary artery insufficiency among males.

The phase IV clinical study analyzes what interactions people have when they take Unisom and Tylenol w/ codeine. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Unisom?

Unisom has active ingredients of doxylamine succinate. It is often used in insomnia. eHealthMe is studying from 3,875 Unisom users. Check the latest studies of Unisom.

What is Tylenol w/ codeine?

Tylenol w/ codeine has active ingredients of acetaminophen; codeine phosphate. It is often used in pain. eHealthMe is studying from 8,107 Tylenol w/ codeine users. Check the latest studies of Tylenol w/ codeine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 24, 2026

21 people who take Unisom and Tylenol w/ codeine together, and have interactions are studied.

Unisom and Tylenol w/ codeine drug interactions.

What are the common drug interactions of Unisom and Tylenol W/ Codeine, by gender? *:

female:

Drug exposure during pregnancy
Gestational diabetes (diabetes in pregnancy)
Pregnancy induced hypertension
Abnormal labour
Feeding disorder neonatal (when newborn refuse to drink milk)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Lacrimation increased
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Nasopharyngitis (inflammation of the nasopharynx)

male:

Coronary artery insufficiency (insufficiency of artery to carry blood to heart)
Intra-uterine death
Non-cardiac chest pain
Pulmonary congestion (congestion in the lungs)
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Bladder obstruction
Cardiomegaly (increased size of heart than normal)
Death
Hepatic steatosis (fatty liver disease)

What are the common drug interactions of Unisom and Tylenol W/ Codeine, by age (0-1 to 60+)? *:

0-1:

Feeding disorder neonatal (when newborn refuse to drink milk)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Lacrimation increased
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Premature baby
Weight gain poor

2-9:

n/a

10-19:

n/a

20-29:

Drug exposure during pregnancy
Beta haemolytic streptococcal infection (infection with streptococcus pyogenes, a beta-haemolytic bacterium cause mild to moderately severe respiratory tract, skin, and soft tissue)
Postpartum haemorrhage (bleeding in woman after she has given birth)
Abdominal pain
Bradycardia (abnormally slow heart action)
Chorioamnionitis (inflammation of the fetal membranes (amnion and chorion) due to a bacterial infection)
Complications of maternal exposure to therapeutic drugs
Culture urine positive
Haemorrhage (bleeding)
Live birth

30-39:

Drug exposure during pregnancy
Gestational diabetes (diabetes in pregnancy)
Pregnancy induced hypertension
Abnormal labour
Nasopharyngitis (inflammation of the nasopharynx)
Nephrolithiasis (calculi in the kidneys)

40-49:

n/a

50-59:

Coronary artery insufficiency (insufficiency of artery to carry blood to heart)
Pulmonary congestion (congestion in the lungs)
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Cardiomegaly (increased size of heart than normal)
Death
Hepatic steatosis (fatty liver disease)
Myocardial fibrosis (a condition in which the heart's muscle cells are impaired)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Non-cardiac chest pain

60+:

Fall

What are the existing conditions these people have? *

Tobacco Withdrawal Symptoms: 6 people, 28.57%
Suicide Attempt: 6 people, 28.57%
Psoriasis (immune-mediated disease that affects the skin): 6 people, 28.57%
Overdose: 6 people, 28.57%
Hand Fracture: 6 people, 28.57%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 28.57%
Back Pain: 6 people, 28.57%
Agitation (state of anxiety or nervous excitement): 6 people, 28.57%
Abscess (pus): 6 people, 28.57%
Migraine (headache): 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

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