Uptravi and Vicodin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Uptravi (selexipag) and Vicodin (acetaminophen; hydrocodone bitartrate). Common drug interactions include oxygen consumption increased among females and cough among males.

The phase IV clinical study analyzes what interactions people have when they take Uptravi and Vicodin. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Uptravi?

Uptravi has active ingredients of selexipag. eHealthMe is studying from 26,576 Uptravi users. Check the latest studies of Uptravi.

What is Vicodin?

Vicodin has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 63,357 Vicodin users. Check the latest studies of Vicodin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 23, 2026

12 people who take Uptravi and Vicodin together, and have interactions are studied.

What are the common drug interactions of Uptravi and Vicodin, by gender? *:

female:

Oxygen consumption increased
Dyspnoea exertional (breathlessness or shortness of breath)
Asthenia (weakness)
Arthralgia (joint pain)
Hypotension (abnormally low blood pressure)
Weight increased
Facial pain
Headache (pain in head)
Pain in extremity
Peripheral swelling

male:

Cough
Dyspnoea (difficult or laboured respiration)
Headache (pain in head)
Pain in jaw
Weight decreased
Oedema (fluid collection in tissue)
Oedema peripheral (superficial swelling)

What are the common drug interactions of Uptravi and Vicodin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Chest pain
Drug intolerance (drug sensitivity)
Dyspnoea (difficult or laboured respiration)
Facial pain
Fatigue (feeling of tiredness)
Flushing (the warm, red condition of human skin)
Head discomfort
Headache (pain in head)
Hypotension (abnormally low blood pressure)
Limb discomfort (discomfort in leg)

50-59:

Dyspnoea (difficult or laboured respiration)
Nausea (feeling of having an urge to vomit)
Arthralgia (joint pain)
Asthenia (weakness)
Cardiac failure
Cardiac failure acute
Chills (felling of cold)
Cor pulmonale (enlargement of the right ventricle of the heart)
Dyspnoea exertional (breathlessness or shortness of breath)
Fluid overload (too much fluid in the blood)

60+:

Headache (pain in head)
Oedema (fluid collection in tissue)
Pulmonary embolism (blockage of the main artery of the lung)
Pulmonary hypertension (increase in blood pressure in the lung artery)
Cough
Dyspnoea (difficult or laboured respiration)
Weight decreased
Arthralgia (joint pain)
Diarrhoea
Facial pain

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 8 people, 66.67%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 4 people, 33.33%
Nausea (feeling of having an urge to vomit): 1 person, 8.33%
Hyperlipidaemia (presence of excess lipids in the blood): 1 person, 8.33%
High Blood Pressure: 1 person, 8.33%
Dizziness: 1 person, 8.33%
Diarrhea: 1 person, 8.33%
Chronic Left Ventricular Failure (long lasting functional impairment of left ventricle of heart): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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