Urso 250 and Solu-cortef drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Urso 250 (ursodiol) and Solu-cortef (hydrocortisone sodium succinate). Common drug interactions include cerebral haemorrhage among females and febrile neutropenia among males.

The phase IV clinical study analyzes what interactions people have when they take Urso 250 and Solu-cortef. It is created by eHealthMe based on reports of 57 people who take the same drugs from the FDA, and is updated regularly.

What is Urso 250?

Urso 250 has active ingredients of ursodiol. eHealthMe is studying from 5,080 Urso 250 users. Check the latest studies of Urso 250.

What is Solu-cortef?

Solu-cortef has active ingredients of hydrocortisone sodium succinate. eHealthMe is studying from 7,983 Solu-cortef users. Check the latest studies of Solu-cortef.

On Jul, 31, 2026

57 people who take Urso 250 and Solu-cortef together, and have interactions are studied.

Urso 250 and Solu-cortef drug interactions.

What are the common drug interactions of Urso 250 and Solu-Cortef, by gender? *:

female:

Cerebral haemorrhage (bleeding within the brain)
Chest discomfort
Chest pain
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Haematemesis (vomiting of blood)
Hepatic vein occlusion (blockage of the hepatic vein)
Hyperventilation

male:

Febrile neutropenia (fever with reduced white blood cells)
Hepatic vein occlusion (blockage of the hepatic vein)
Liver disorder (liver diseases)
Renal failure (kidney dysfunction)
Anaemia (lack of blood)
Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Blood creatinine increased
Cytomegalovirus enterocolitis (virus infection of intestine and colon)
Gamma-glutamyltransferase increased
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)

What are the common drug interactions of Urso 250 and Solu-Cortef, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Acute respiratory distress syndrome
Epistaxis (bleed from the nose)
Congestive cardiomyopathy (weakening of heart muscle)
Haematemesis (vomiting of blood)
Nausea (feeling of having an urge to vomit)
Pulmonary haemorrhage (acute bleeding from the lung)
Renal failure (kidney dysfunction)
Pulmonary oedema (fluid accumulation in the lungs)
Respiratory distress (difficulty in breathing)
Vomiting

10-19:

Febrile neutropenia (fever with reduced white blood cells)
Hepatic vein occlusion (blockage of the hepatic vein)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Pericardial effusion (fluid around the heart)
Pulmonary oedema (fluid accumulation in the lungs)
Respiratory disorder (respiratory disease)
Acute respiratory distress syndrome
Haemorrhage intracranial (bleeding within the skull)
Pneumonia
Renal failure acute (rapid kidney dysfunction)

20-29:

n/a

30-39:

Renal impairment (severely reduced kidney function)
Pleural effusion (water on the lungs)
Pyrexia (fever)
Acute respiratory failure
Blood pressure increased
Brain natriuretic peptide increased
Capillary permeability increased (increased ability of small blood vessels to pass fluid in and out)
Chest discomfort
Chest pain
Dyspnoea (difficult or laboured respiration)

40-49:

Cardiac failure congestive
Cardiomegaly (increased size of heart than normal)
Hepatic steatosis (fatty liver disease)
Liver disorder (liver diseases)
Platelet count decreased
White blood cell count decreased
Acute graft versus host disease (acute complication following an allogeneic tissue/blood transplant)
Alanine aminotransferase increased
Anaemia (lack of blood)
Blood bilirubin increased

50-59:

Acute febrile neutrophilic dermatosis (skin disease characterized by the sudden onset of fever, leukocytosis, and tender)
Blood alkaline phosphatase increased
Engraftment syndrome (inflammatory condition during neutrophil recovery after hematopoietic stem cell transplantation)
Gamma-glutamyltransferase increased
Infection
Interstitial lung disease
Pyrexia (fever)
Renal failure acute (rapid kidney dysfunction)

60+:

Abdominal pain
Sepsis (a severe blood infection that can lead to organ failure and death)
Infective spondylitis (infective inflammation of a spinal joint; characterized by pain and stiffness)
Neuropathy peripheral (surface nerve damage)
Stomatitis (inflammation of mucous membrane of mouth)
Vomiting
Acute hepatic failure
Cytomegalovirus enterocolitis (virus infection of intestine and colon)
Demyelination (loss of the myelin covering of some nerve fibres resulting in their impaired function)
Disseminated intravascular coagulation (systemic activation of blood coagulation)

What are the existing conditions these people have? *

Immunodeficiency Disorders: 21 people, 36.84%
Fever: 4 people, 7.02%
Febrile Neutropenia (fever with reduced white blood cells): 4 people, 7.02%
Neutrophil Count Decreased (less than normal number of neutrophil a type of blood cell): 3 people, 5.26%
Iron Overload: 3 people, 5.26%
Asthma: 3 people, 5.26%

* Approximation only. Some reports may have incomplete information.

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