Urso 250 and Uniphyl drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Urso 250 (ursodiol) and Uniphyl (theophylline). Common drug interactions include leukocytoclastic vasculitis among females and blood bilirubin increased among males.

The phase IV clinical study analyzes what interactions people have when they take Urso 250 and Uniphyl. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Urso 250?

Urso 250 has active ingredients of ursodiol. eHealthMe is studying from 5,080 Urso 250 users. Check the latest studies of Urso 250.

What is Uniphyl?

Uniphyl has active ingredients of theophylline. eHealthMe is studying from 3,086 Uniphyl users. Check the latest studies of Uniphyl.

On Jul, 11, 2026

30 people who take Urso 250 and Uniphyl together, and have interactions are studied.

What are the common drug interactions of Urso 250 and Uniphyl, by gender? *:

female:

Leukocytoclastic vasculitis (inflammation of small blood vessels (usually post-capillary venules in the dermis), characterized by palpable purpura)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Allergic granulomatous angiitis (allergic inflammation of a blood vessel or lymph duct)
Vasculitis (inflammation of a blood vessel or blood vessels)
Nephritis interstitial (a kidney condition characterized by swelling in between the kidney tubules)
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Asthma
Cerebral infarction (less blood supply to brain resulting tissue damage)
Haematuria (presence of blood in urine)
Malaise (a feeling of general discomfort or uneasiness)

male:

Blood bilirubin increased
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Blood creatinine increased
Blood pressure diastolic increased
Disease progression
Gamma-glutamyltransferase increased
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Obliterative bronchiolitis (bronchiolar inflammation)
Pleurisy (inflammation of the pleurae, which causes pain when breathing)
Sepsis (a severe blood infection that can lead to organ failure and death)

What are the common drug interactions of Urso 250 and Uniphyl, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Blood bilirubin increased
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Obliterative bronchiolitis (bronchiolar inflammation)
Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)
Sepsis (a severe blood infection that can lead to organ failure and death)

30-39:

n/a

40-49:

n/a

50-59:

Anaemia (lack of blood)
Aplasia pure red cell (type of anaemia affecting the precursors to red blood cells but not to white blood cells)

60+:

Leukocytoclastic vasculitis (inflammation of small blood vessels (usually post-capillary venules in the dermis), characterized by palpable purpura)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Nephropathy (damage to or disease of a kidney)
Nephrotic syndrome (kidney disease with proteinuria, hypoalbuminemia, and oedema)
Proteinuria (presence of protein in the urine)
Rhinitis allergic (inflammation of the nasal airways due to allergy)
Altered state of consciousness (altered state of mind)
Autoimmune thrombocytopenia (isolated low platelet count (thrombocytopenia) with normal bone marrow and the absence of other causes of thrombocytopenia)
Cough
Fall

What are the existing conditions these people have? *

Asthma: 19 people, 63.33%
Gallstones (stone formation by bile component): 17 people, 56.67%
High Blood Pressure: 15 people, 50.00%
Allergic Rhinitis: 15 people, 50.00%
Cerebral Infarction (less blood supply to brain resulting tissue damage): 10 people, 33.33%
Hepatitis C: 5 people, 16.67%
Back Pain: 4 people, 13.33%
Hyperuricaemia (level of uric acid in the blood that is abnormally high): 3 people, 10.00%
Gastritis (inflammation of stomach): 3 people, 10.00%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 3 people, 10.00%

* Approximation only. Some reports may have incomplete information.

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