Ursodeoxycholic acid and Hydrocortisone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ursodeoxycholic acid (ursodiol) and Hydrocortisone (hydrocortisone). Common drug interactions include acute graft versus host disease in skin among females and renal failure acute among males.

The phase IV clinical study analyzes what interactions people have when they take Ursodeoxycholic acid and Hydrocortisone. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Ursodeoxycholic acid?

Ursodeoxycholic acid has active ingredients of ursodiol. It is often used in biliary cirrhosis primary. eHealthMe is studying from 7,528 Ursodeoxycholic acid users. Check the latest studies of Ursodeoxycholic acid.

What is Hydrocortisone?

Hydrocortisone has active ingredients of hydrocortisone. It is often used in addison's disease. eHealthMe is studying from 40,425 Hydrocortisone users. Check the latest studies of Hydrocortisone.

On Jul, 13, 2026

26 people who take Ursodeoxycholic acid and Hydrocortisone together, and have interactions are studied.

Ursodeoxycholic acid and Hydrocortisone drug interactions.

What are the common drug interactions of Ursodeoxycholic Acid and Hydrocortisone, by gender? *:

female:

Acute graft versus host disease in skin (acute complication on skin following an allogeneic tissue/blood transplant)
Alanine aminotransferase increased
Aspartate aminotransferase increased
Blood alkaline phosphatase increased
Blood lactate dehydrogenase increased
Gamma-glutamyltransferase increased
Bile duct cancer
Bile duct stricture (narrowed areas of the bile ducts that can be either benign or malignant)
Cellulitis (infection under the skin)
Cholangitis (infection of the bile duct)

male:

Renal failure acute (rapid kidney dysfunction)
Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Cardiogenic shock (inadequate circulation of blood)
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Cytomegalovirus viraemia (cytomegalo virus in blood stream)
Death
Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Enterococcal infection
Escherichia bacteraemia (presence of bacteria escherichia coli in the blood)

What are the common drug interactions of Ursodeoxycholic Acid and Hydrocortisone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Renal failure acute (rapid kidney dysfunction)

20-29:

Febrile neutropenia (fever with reduced white blood cells)
Hepatotoxicity (chemical-driven liver damage)
Renal failure acute (rapid kidney dysfunction)
Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Death
Drug ineffective
Insomnia (sleeplessness)
Platelet count decreased
Restlessness (not able to rest)
Suicidal ideation

30-39:

Acute hepatic failure
Cardiogenic shock (inadequate circulation of blood)
Death
Gastrointestinal stoma complication (complication of an opening surgically made in digestive tract)
Mallory-weiss syndrome (gastro-oesophageal laceration syndrome refers to bleeding from tears)
Thyrotoxic crisis (a life threatening condition due to excess secretion of thyroid hormone)

40-49:

Acute graft versus host disease in skin (acute complication on skin following an allogeneic tissue/blood transplant)
Bile duct cancer
Bile duct stricture (narrowed areas of the bile ducts that can be either benign or malignant)
Cholangitis (infection of the bile duct)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Cystitis viral (inflammation of the wall of the bladder by virus)
Human herpesvirus 6 infection
Hypotension (abnormally low blood pressure)
Loss of consciousness
Nausea (feeling of having an urge to vomit)

50-59:

Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haemorrhage (bleeding)
Loss of consciousness
Otitis externa (external ear infection)
Pallor
Rash
Rash macular (small, flat red spots)
Tumour invasion (starting of tumour)

60+:

Cerebral infarction (less blood supply to brain resulting tissue damage)
Alanine aminotransferase increased
Enterococcal infection
Escherichia bacteraemia (presence of bacteria escherichia coli in the blood)
Fall
Human herpesvirus 6 infection
Lung infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung)
Malignant neoplasm progression (cancer tumour came back)
Multi-organ failure (multisystem organ failure)
Renal failure acute (rapid kidney dysfunction)

What are the existing conditions these people have? *

Colon Cancer: 6 people, 23.08%
Nausea And Vomiting: 4 people, 15.38%
Nausea (feeling of having an urge to vomit): 4 people, 15.38%
Septic Shock (shock due to blood infection): 3 people, 11.54%
Device Related Infection: 3 people, 11.54%
Aspergillosis (an infection caused by a fungus called aspergillus): 3 people, 11.54%
Blood Albumin Decreased: 3 people, 11.54%
Blood Bilirubin Increased: 3 people, 11.54%
Bone Marrow Conditioning Regimen: 3 people, 11.54%
Cancer Pain: 3 people, 11.54%

* Approximation only. Some reports may have incomplete information.

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