Ursodeoxycholic acid and Sovaldi drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ursodeoxycholic acid (ursodiol) and Sovaldi (sofosbuvir). Common drug interactions include haemoglobin decreased among females and hepatocellular carcinoma among males.

The phase IV clinical study analyzes what interactions people have when they take Ursodeoxycholic acid and Sovaldi. It is created by eHealthMe based on reports of 34 people who take the same drugs from the FDA, and is updated regularly.

What is Ursodeoxycholic acid?

Ursodeoxycholic acid has active ingredients of ursodiol. It is often used in biliary cirrhosis primary. eHealthMe is studying from 7,528 Ursodeoxycholic acid users. Check the latest studies of Ursodeoxycholic acid.

What is Sovaldi?

Sovaldi has active ingredients of sofosbuvir. eHealthMe is studying from 12,697 Sovaldi users. Check the latest studies of Sovaldi.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 21, 2026

34 people who take Ursodeoxycholic acid and Sovaldi together, and have interactions are studied.

Ursodeoxycholic acid and Sovaldi drug interactions.

What are the common drug interactions of Ursodeoxycholic Acid and Sovaldi, by gender? *:

female:

Haemoglobin decreased
Blood bilirubin increased
Pyelonephritis (inflammation of kidney caused by bacteria)
Cerebral infarction (less blood supply to brain resulting tissue damage)
Dehydration (dryness resulting from the removal of water)
Drug ineffective
Hepatocellular carcinoma (liver cancer)
Asthenia (weakness)
Cardiac failure
Pneumonia

male:

Hepatocellular carcinoma (liver cancer)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Headache (pain in head)
Heart rate increased
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Muscular weakness (muscle weakness)
Asthenia (weakness)
Bradycardia (abnormally slow heart action)
Cardiac failure
Decreased appetite

What are the common drug interactions of Ursodeoxycholic Acid and Sovaldi, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Anaemia (lack of blood)
Chronic kidney disease
Hepatitis c
Hepatocellular carcinoma (liver cancer)
Muscular weakness (muscle weakness)
Hypoaesthesia (reduced sense of touch or sensation)
Pleural effusion (water on the lungs)
Rash
Rash erythematous (redness of the skin)

50-59:

Blood bilirubin increased
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Ascites (accumulation of fluid in the abdominal cavity)
Drug ineffective
Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
Enzyme abnormality
Fatigue (feeling of tiredness)
Gastric varices
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Hepatitis acute

60+:

Haemoglobin decreased
Blood bilirubin increased
Hepatitis c
Pneumonia
Tricuspid valve incompetence (inefficient heart valve)
Cystitis (inflammation of the wall of the bladder)
Cystitis-like symptom
Disturbance in attention
Headache (pain in head)
Heart rate increased

What are the existing conditions these people have? *

Hepatitis C: 10 people, 29.41%
High Blood Pressure: 8 people, 23.53%
Hepatic Cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue): 3 people, 8.82%
Diabetes: 3 people, 8.82%
Viral Infection: 2 people, 5.88%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 5.88%
Cholestasis (a condition where bile cannot flow from the liver to the duodenum): 2 people, 5.88%
Cardiac Failure: 2 people, 5.88%
Allergic Rhinitis: 2 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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