Ursodiol and Letairis drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ursodiol (ursodiol) and Letairis (ambrisentan). Common drug interactions include atrial fibrillation among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Ursodiol and Letairis. It is created by eHealthMe based on reports of 76 people who take the same drugs from the FDA, and is updated regularly.

What is Ursodiol?

Ursodiol has active ingredients of ursodiol. It is often used in primary biliary cirrhosis. eHealthMe is studying from 19,061 Ursodiol users. Check the latest studies of Ursodiol.

What is Letairis?

Letairis has active ingredients of ambrisentan. It is often used in pulmonary hypertension. eHealthMe is studying from 94,041 Letairis users. Check the latest studies of Letairis.

On Jul, 18, 2026

76 people who take Ursodiol and Letairis together, and have interactions are studied.

Ursodiol and Letairis drug interactions.

What are the common drug interactions of Ursodiol and Letairis, by gender? *:

female:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bone pain
Brain natriuretic peptide increased
Cardiac failure
Cardiomegaly (increased size of heart than normal)
Contusion (a type of hematoma of tissue in which capillaries)
Decreased appetite
Depression
Dilatation ventricular
Dysphagia (a condition in which swallowing is difficult or painful)

male:

Dyspnoea (difficult or laboured respiration)
Cough
Gastric haemorrhage (bleeding stomach)
Gastritis (inflammation of stomach)
Gastroduodenitis (an inflammation of the mucous membrane of the stomach and duodenum)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Iron deficiency anaemia
Leukaemia recurrent (repeat cancer of bone marrow or blood cells)
Lung transplant

What are the common drug interactions of Ursodiol and Letairis, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Acute respiratory failure
Brain natriuretic peptide increased
Cardiomegaly (increased size of heart than normal)
Chest discomfort
Death
Dilatation ventricular
Dyspnoea (difficult or laboured respiration)
Fluid overload (too much fluid in the blood)
Fluid retention (an abnormal accumulation of fluid in the blood)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)

30-39:

n/a

40-49:

Haemorrhage (bleeding)
Headache (pain in head)
Oedema (fluid collection in tissue)
Anaemia (lack of blood)

50-59:

Throat irritation
Weight decreased
Cardiac failure
Death
Diarrhoea
Fall
Influenza
Localised oedema (fluid retention in a particular part of the body)
Nausea (feeling of having an urge to vomit)
Oedema (fluid collection in tissue)

60+:

Dyspnoea (difficult or laboured respiration)
Cough
Death
Headache (pain in head)
Nasopharyngitis (inflammation of the nasopharynx)
Peripheral swelling
Pneumonia
Renal failure acute (rapid kidney dysfunction)
Asthenia (weakness)
Chest discomfort

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 47 people, 61.84%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 5.26%
Gallstones (stone formation by bile component): 4 people, 5.26%

* Approximation only. Some reports may have incomplete information.

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