Ursodiol and Maxipime drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ursodiol (ursodiol) and Maxipime (cefepime hydrochloride). Common drug interactions include graft versus host disease among females and cytokine release syndrome among males.

The phase IV clinical study analyzes what interactions people have when they take Ursodiol and Maxipime. It is created by eHealthMe based on reports of 41 people who take the same drugs from the FDA, and is updated regularly.

What is Ursodiol?

Ursodiol has active ingredients of ursodiol. It is often used in primary biliary cirrhosis. eHealthMe is studying from 19,061 Ursodiol users. Check the latest studies of Ursodiol.

What is Maxipime?

Maxipime has active ingredients of cefepime hydrochloride. eHealthMe is studying from 4,279 Maxipime users. Check the latest studies of Maxipime.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 17, 2026

41 people who take Ursodiol and Maxipime together, and have interactions are studied.

Ursodiol and Maxipime drug interactions.

What are the common drug interactions of Ursodiol and Maxipime, by gender? *:

female:

Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Platelet count decreased
White blood cell count decreased
C-reactive protein increased
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Pyrexia (fever)
Acinetobacter infection (infection by group of bacteria commonly found in soil and water)
Alanine aminotransferase increased
Aspartate aminotransferase increased
Bacteraemia (presence of bacteria in the blood)

male:

Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Dyspnoea (difficult or laboured respiration)
Sepsis (a severe blood infection that can lead to organ failure and death)
Agitation (state of anxiety or nervous excitement)
Headache (pain in head)
Hypoxia (low oxygen in tissues)
Pericardial effusion (fluid around the heart)
Pneumonia
Acute lymphocytic leukaemia (cancer of the white blood cells)
Ammonia increased

What are the common drug interactions of Ursodiol and Maxipime, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Acinetobacter infection (infection by group of bacteria commonly found in soil and water)
Diarrhoea
Diarrhoea haemorrhagic (bloody diarrhoea)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Haematoma (collection of blood outside the blood vessels)
Pleural effusion (water on the lungs)
Pyrexia (fever)
Septic shock (shock due to blood infection)
Tooth abscess (pus formation in tooth)

10-19:

Diarrhoea
Electrocardiogram qt prolonged
Encephalopathy (functioning of the brain is affected by some agent or condition)
Fatigue (feeling of tiredness)
Fluid overload (too much fluid in the blood)
Gallbladder enlargement
Gastrointestinal oedema (excessive build-up of fluid in the gastrointestinal tract tissues)
Hallucination (an experience involving the perception of something not present)
Headache (pain in head)
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)

20-29:

n/a

30-39:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Nausea (feeling of having an urge to vomit)
Pneumonia fungal
Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)
Rash

40-49:

Pneumonia
Erythema (redness of the skin)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Interstitial lung disease
Posterior reversible encephalopathy syndrome (posterior reversible encephalopathy syndrome (pres), also known as reversible posterior leukoencephalopathy syndrome (rpls), is a syndrome characterized by headache, confusion, seizures and visual loss)
Sepsis (a severe blood infection that can lead to organ failure and death)
Aggression
Agitation (state of anxiety or nervous excitement)
Amblyopia (lazy eye)
Blood calcium decreased

50-59:

Febrile neutropenia (fever with reduced white blood cells)
Sepsis (a severe blood infection that can lead to organ failure and death)
Blood creatinine increased
Blood pressure decreased
Blood urea increased
Body temperature increased
C-reactive protein increased
Hypercalcaemia (elevated calcium (ca+) level in the blood)
Neutropenia (an abnormally low number of neutrophils)
Respiratory failure (inadequate gas exchange by the respiratory system)

60+:

Alanine aminotransferase increased
Aspartate aminotransferase increased
C-reactive protein increased
Diarrhoea
Fibrin d dimer increased
Gamma-glutamyltransferase increased
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Hypotension (abnormally low blood pressure)
Liver disorder (liver diseases)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)

What are the existing conditions these people have? *

Fever: 11 people, 26.83%
Liver Disorder (liver diseases): 9 people, 21.95%
Adult T-Cell Lymphoma/leukaemia (cancer of the immune system's own t-cells): 9 people, 21.95%
Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 8 people, 19.51%
Constipation: 8 people, 19.51%
Rashes (redness): 6 people, 14.63%
Nausea (feeling of having an urge to vomit): 6 people, 14.63%
High Blood Pressure: 6 people, 14.63%
Abdominal Pain: 5 people, 12.20%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 5 people, 12.20%

* Approximation only. Some reports may have incomplete information.

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