Vagifem and Asacol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vagifem (estradiol) and Asacol (mesalamine). Common drug interactions include dyspnoea among females and myelodysplastic syndrome among males.

The phase IV clinical study analyzes what interactions people have when they take Vagifem and Asacol. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Vagifem?

Vagifem has active ingredients of estradiol. It is often used in vulvovaginal dryness. eHealthMe is studying from 6,263 Vagifem users. Check the latest studies of Vagifem.

What is Asacol?

Asacol has active ingredients of mesalamine. It is often used in ulcerative colitis. eHealthMe is studying from 20,618 Asacol users. Check the latest studies of Asacol.

On Jul, 15, 2026

17 people who take Vagifem and Asacol together, and have interactions are studied.

What are the common drug interactions of Vagifem and Asacol, by gender? *:

female:

Dyspnoea (difficult or laboured respiration)
Periodontitis (inflammation of the tissue around the teeth)
Sensitivity of teeth
Tooth disorder (tooth disease)
Tooth fracture
Bone density decreased
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Hyperhidrosis (abnormally increased sweating)
Oral pain
Pain in jaw

male:

Myelodysplastic syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged)

What are the common drug interactions of Vagifem and Asacol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Exostosis (formation of new bone on the surface of a bone)
Hip arthroplasty
Postoperative heterotopic calcification (process by which bone tissue forms outside of the skeleton after operative)

50-59:

Nausea (feeling of having an urge to vomit)
Arthralgia (joint pain)
Arthropathy
Dyspepsia (indigestion)
Headache (pain in head)
Hyperhidrosis (abnormally increased sweating)
Injection site bruising
Injection site pain
Joint stiffness
Local swelling (swelling at the site of some application of substance or injury)

60+:

Dyspnoea (difficult or laboured respiration)
Bone atrophy (decrease in bone mass)
Tooth disorder (tooth disease)
Tooth fracture
Bone density decreased
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Oral pain
Pain in jaw
Tooth abscess (pus formation in tooth)
Anxiety

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 29.41%
Pain: 5 people, 29.41%
High Blood Pressure: 5 people, 29.41%
High Blood Cholesterol: 4 people, 23.53%
Depression: 4 people, 23.53%
Hypersensitivity: 4 people, 23.53%
Rhinitis (a medical term for irritation and inflammation of the mucous membrane inside the nose): 3 people, 17.65%
Osteoporosis (bones weak and more likely to break): 3 people, 17.65%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 3 people, 17.65%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 2 people, 11.76%

* Approximation only. Some reports may have incomplete information.

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