Valacyclovir hydrochloride and Tacrolimus drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Valacyclovir hydrochloride (valacyclovir hydrochloride) and Tacrolimus (tacrolimus). Common drug interactions include stomatitis among females and squamous cell carcinoma of skin among males.

The phase IV clinical study analyzes what interactions people have when they take Valacyclovir hydrochloride and Tacrolimus. It is created by eHealthMe based on reports of 323 people who take the same drugs from the FDA, and is updated regularly.

What is Valacyclovir hydrochloride?

Valacyclovir hydrochloride has active ingredients of valacyclovir hydrochloride. It is often used in herpes zoster. eHealthMe is studying from 12,929 Valacyclovir hydrochloride users. Check the latest studies of Valacyclovir hydrochloride.

What is Tacrolimus?

Tacrolimus has active ingredients of tacrolimus. It is often used in kidney transplant. eHealthMe is studying from 116,159 Tacrolimus users. Check the latest studies of Tacrolimus.



On Sep, 15, 2025

323 people who take Valacyclovir hydrochloride and Tacrolimus together, and have interactions are studied.

Valacyclovir hydrochloride and Tacrolimus drug interactions.

What are the common drug interactions of Valacyclovir Hydrochloride and Tacrolimus, by gender? *:

female:

  1. Stomatitis (inflammation of mucous membrane of mouth)
  2. Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
  3. Actinic keratosis (skin disease due to sun exposure)
  4. Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
  5. Diarrhoea
  6. Renal impairment (severely reduced kidney function)
  7. Viral haemorrhagic cystitis (lower urinary tract symptoms that include haematuria and irritative voiding symptoms)
  8. Drug ineffective
  9. Dyspnoea (difficult or laboured respiration)
  10. Interstitial lung disease

male:

  1. Squamous cell carcinoma of skin (a cancer of a kind of epithelial cell, the squamous cell. these cells are the main part of the epidermis of the skin)
  2. Actinic keratosis (skin disease due to sun exposure)
  3. Respiratory failure (inadequate gas exchange by the respiratory system)
  4. Acute graft versus host disease in skin (acute complication on skin following an allogeneic tissue/blood transplant)
  5. Colitis (inflammation of colon)
  6. Cryptosporidiosis infection (an intestinal disease caused by the cryptosporidium parasite)
  7. Pneumonia
  8. Liver transplant rejection (failure of liver transplant)
  9. Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
  10. Influenza

What are the common drug interactions of Valacyclovir Hydrochloride and Tacrolimus, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

  1. Adenovirus infection
  2. Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
  3. Body temperature fluctuation
  4. Dehydration (dryness resulting from the removal of water)
  5. Diarrhoea
  6. Ear infection
  7. Febrile neutropenia (fever with reduced white blood cells)
  8. Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
  9. Gastrointestinal infection (infection of stomach and intestine)
  10. Lymphopenia (an abnormally low level of lymphocytes in the blood)

10-19:

  1. Axonal neuropathy (dysfunction of axon nerves)
  2. Aplastic anaemia (blood disorder in which the body's bone marrow doesn't make enough new blood cells)
  3. Febrile neutropenia (fever with reduced white blood cells)
  4. Mucosal inflammation (infection of mucous membrane)
  5. Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
  6. Brain abscess
  7. Cystitis haemorrhagic (blood in the urine and painful voiding)
  8. Dyspnoea (difficult or laboured respiration)
  9. Fluid retention (an abnormal accumulation of fluid in the blood)
  10. Infection

20-29:

  1. Immunosuppressant drug level increased
  2. Thrombotic microangiopathy (a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury)
  3. Anaemia (lack of blood)
  4. Epstein-barr virus associated lymphoma (epstein-barr virus associated tumour)
  5. Renal failure (kidney dysfunction)
  6. Cytomegalovirus test positive
  7. Acute graft versus host disease in skin (acute complication on skin following an allogeneic tissue/blood transplant)
  8. Interstitial lung disease
  9. Liver transplant rejection (failure of liver transplant)
  10. Haematuria (presence of blood in urine)

30-39:

  1. Pyrexia (fever)
  2. Pneumonia
  3. Leukopenia (less number of white blood cells in blood)
  4. Neutropenia (an abnormally low number of neutrophils)
  5. Respiratory failure (inadequate gas exchange by the respiratory system)
  6. Aplasia pure red cell (type of anaemia affecting the precursors to red blood cells but not to white blood cells)
  7. Myelosuppression (a decrease in the production of blood cells)
  8. Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
  9. Fungal infection
  10. Headache (pain in head)

40-49:

  1. Actinic keratosis (skin disease due to sun exposure)
  2. Squamous cell carcinoma of skin (a cancer of a kind of epithelial cell, the squamous cell. these cells are the main part of the epidermis of the skin)
  3. Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
  4. Cerebral toxoplasmosis (parasitic disease of brain caused by the protozoan toxoplasma gondii)
  5. Gastric varices
  6. Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  7. Lymphocytosis (an increase in the number or proportion of lymphocytes in the blood)
  8. Mononucleosis syndrome (an infection that produces flu-like symptoms, and usually goes away on its own in a few weeks)
  9. Portal hypertension (increase in the blood pressure within a system of veins called the portal venous system)
  10. Thrombocytopenia (decrease of platelets in blood)

50-59:

  1. Enterococcus test positive
  2. Haemoglobin decreased
  3. Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
  4. Oral herpes (viral infection of mouth)
  5. Peritonitis bacterial (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs by bacterial)
  6. Thrombocytopenia (decrease of platelets in blood)
  7. Abdominal discomfort
  8. Anaemia (lack of blood)
  9. Asthenia (weakness)
  10. Blood glucose increased

60+:

  1. Drug ineffective
  2. Squamous cell carcinoma of skin (a cancer of a kind of epithelial cell, the squamous cell. these cells are the main part of the epidermis of the skin)
  3. Urinary tract infection
  4. Dizziness
  5. Hepatic enzyme increased
  6. Insomnia (sleeplessness)
  7. Platelet count decreased
  8. Hospitalisation
  9. Acute graft versus host disease in skin (acute complication on skin following an allogeneic tissue/blood transplant)
  10. Acute myeloid leukaemia recurrent (acute cancer in which the bone marrow makes abnormal myeloblast- recurrent)

What are the existing conditions these people have? *

  1. Bone Marrow Conditioning Regimen: 31 people, 9.60%
  2. High Blood Pressure: 30 people, 9.29%
  3. Pain: 24 people, 7.43%
  4. Immunodeficiency Disorders: 24 people, 7.43%
  5. Nausea (feeling of having an urge to vomit): 23 people, 7.12%
  6. Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body): 21 people, 6.50%
  7. Fungal Infection: 19 people, 5.88%
  8. Febrile Bone Marrow Aplasia (bone marrow greatly decreases or stops production of blood cells): 18 people, 5.57%
  9. Venoocclusive Disease (small veins in the liver are obstructed): 17 people, 5.26%
  10. Blood Disorder: 17 people, 5.26%

* Approximation only. Some reports may have incomplete information.

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Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all side effects of Valacyclovir hydrochloride:

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Browse all interactions between Valacyclovir hydrochloride and drugs from A to Z:

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Browse all interactions between Tacrolimus and drugs from A to Z:

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How the study uses the data?

The study uses data from the FDA. It is based on valacyclovir hydrochloride and tacrolimus (the active ingredients of Valacyclovir hydrochloride and Tacrolimus, respectively), and Valacyclovir hydrochloride and Tacrolimus (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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