Valacyclovir and Cortef drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Valacyclovir (valacyclovir hydrochloride) and Cortef (hydrocortisone). Common drug interactions include pain among females and headache among males.

The phase IV clinical study analyzes what interactions people have when they take Valacyclovir and Cortef. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.

What is Valacyclovir?

Valacyclovir has active ingredients of valacyclovir hydrochloride. It is often used in genital herpes. eHealthMe is studying from 42,107 Valacyclovir users. Check the latest studies of Valacyclovir.

What is Cortef?

Cortef has active ingredients of hydrocortisone. It is often used in addison's disease. eHealthMe is studying from 4,254 Cortef users. Check the latest studies of Cortef.

On Jul, 23, 2026

32 people who take Valacyclovir and Cortef together, and have interactions are studied.

Valacyclovir and Cortef drug interactions.

What are the common drug interactions of Valacyclovir and Cortef, by gender? *:

female:

Pain
Fatigue (feeling of tiredness)
Cough
Upper-airway cough syndrome
Blood immunoglobulin g decreased
Blood immunoglobulin m decreased
Blood pressure increased
Infection
Influenza like illness
Infusion site erythema (reddening of the skin at infusion site)

male:

Headache (pain in head)
Muscle strain (an injury to a muscle in which the muscle fibres tear)
Migraine (headache)
Prostate infection
Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)
Cyst (a closed sac)
Dermal cyst
Hypersensitivity
Staphylococcal skin infection (skin infection by an infection with staphylococcus bacteria)
Immunisation reaction

What are the common drug interactions of Valacyclovir and Cortef, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Pericardial effusion (fluid around the heart)
Pleural effusion (water on the lungs)

20-29:

n/a

30-39:

Cough
Fatigue (feeling of tiredness)
Pain
Upper-airway cough syndrome

40-49:

n/a

50-59:

Blood immunoglobulin g decreased
Blood immunoglobulin m decreased
Blood pressure increased
Colitis microscopic (inflammation of colon with diarrhoea and abdominal cramps)
Infection
Influenza like illness
Infusion site erythema (reddening of the skin at infusion site)
Infusion site swelling
Pain
Weight decreased

60+:

Cough
Gastrointestinal infection (infection of stomach and intestine)
Migraine (headache)
Prostate infection
Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)
Cyst (a closed sac)
Dermal cyst
Hypersensitivity
Staphylococcal skin infection (skin infection by an infection with staphylococcus bacteria)
Anaemia (lack of blood)

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 11 people, 34.38%
Constipation: 6 people, 18.75%
Irritable Bowel Syndrome: 5 people, 15.62%
Muscle Spasms (muscle contraction): 5 people, 15.62%
Depression: 5 people, 15.62%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 5 people, 15.62%
Fibromyalgia (a long-term condition which causes pain all over the body): 5 people, 15.62%
Joint Pain: 5 people, 15.62%
Adrenocortical Insufficiency Acute (suddenly adrenal glands do not produce adequate amounts of steroid hormones): 5 people, 15.62%
Neuralgia (pain in one or more nerves): 5 people, 15.62%

* Approximation only. Some reports may have incomplete information.

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