Valacyclovir and Purinethol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Valacyclovir (valacyclovir hydrochloride) and Purinethol (mercaptopurine). Common drug interactions include transaminases increased among females and arthralgia among males.

The phase IV clinical study analyzes what interactions people have when they take Valacyclovir and Purinethol. It is created by eHealthMe based on reports of 40 people who take the same drugs from the FDA, and is updated regularly.

What is Valacyclovir?

Valacyclovir has active ingredients of valacyclovir hydrochloride. It is often used in genital herpes. eHealthMe is studying from 42,107 Valacyclovir users. Check the latest studies of Valacyclovir.

What is Purinethol?

Purinethol has active ingredients of mercaptopurine. It is often used in ulcerative colitis. eHealthMe is studying from 3,810 Purinethol users. Check the latest studies of Purinethol.

On Jul, 12, 2026

40 people who take Valacyclovir and Purinethol together, and have interactions are studied.

Valacyclovir and Purinethol drug interactions.

What are the common drug interactions of Valacyclovir and Purinethol, by gender? *:

female:

Transaminases increased
Dysphagia (a condition in which swallowing is difficult or painful)
Febrile bone marrow aplasia (bone marrow greatly decreases or stops production of blood cells)
Photosensitivity reaction
Abdominal discomfort
Abdominal pain
Angioedema (rapid swelling of the dermis)
Chills (felling of cold)
Conjunctivitis (pink eye)
Dysstasia (difficulty in standing)

male:

Arthralgia (joint pain)
Blood pressure fluctuation
Thrombocytopenia (decrease of platelets in blood)
Adjustment disorder with depressed mood
Back pain
Bladder disorder
Blood pressure diastolic increased
Contusion (a type of hematoma of tissue in which capillaries)
Cough
Dizziness

What are the common drug interactions of Valacyclovir and Purinethol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Grip strength decreased
Hepatomegaly (abnormal enlargement of the liver)
Hypernatraemia (an abnormally high plasma concentration of sodium ions)
Hypertension (high blood pressure)
Loss of proprioception (loss of senses of body and parts)
Mucosal inflammation (infection of mucous membrane)
Nikolsky's sign
Oedema (fluid collection in tissue)
Pain of skin
Paralysis

20-29:

Pyrexia (fever)
Angioedema (rapid swelling of the dermis)
Headache (pain in head)
Injury
Rash
Subdural haematoma (blood collects between the skull and the surface of the brain)
Vomiting

30-39:

Adjustment disorder with depressed mood
Arthralgia (joint pain)
Back pain
Bladder disorder
Blood pressure diastolic increased
Blood pressure fluctuation
Contusion (a type of hematoma of tissue in which capillaries)
Cough
Diarrhoea
Dizziness

40-49:

Subacute combined cord degeneration (subacute combined degeneration of the spinal cord is caused by a vitamin b12 deficiency)
Dysphagia (a condition in which swallowing is difficult or painful)
Febrile bone marrow aplasia (bone marrow greatly decreases or stops production of blood cells)
Hepatic failure (liver failure)
Hepatitis (inflammation of the liver)

50-59:

Arthralgia (joint pain)
Blood pressure fluctuation
Chest pain
Drug level decreased
Dyspnoea (difficult or laboured respiration)
Pneumonia
Acute sinusitis
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Frequent bowel movements
Haematochezia (passage of stools containing blood)

60+:

Liver disorder (liver diseases)
Application site pain
Pyrexia (fever)
Thrombocytopenia (decrease of platelets in blood)
Weight decreased
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Fall
Photosensitivity reaction
Anaemia (lack of blood)
Bone marrow failure

What are the existing conditions these people have? *

Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 9 people, 22.50%
T-Cell Type Acute Leukaemia (a form of cancer of the white blood cells): 7 people, 17.50%
Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 6 people, 15.00%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 3 people, 7.50%
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve): 2 people, 5.00%
Pneumocystis Jiroveci Pneumonia (fungal infection of the lungs): 2 people, 5.00%
Fungal Infection: 2 people, 5.00%
Basal Cell Carcinoma (a skin cancer, it rarely metastasizes or kills): 2 people, 5.00%

* Approximation only. Some reports may have incomplete information.

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