Valacyclovir and Sporanox drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Valacyclovir (valacyclovir hydrochloride) and Sporanox (itraconazole). Common drug interactions include immunosuppressant drug level increased among females and septic shock among males.

The phase IV clinical study analyzes what interactions people have when they take Valacyclovir and Sporanox. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Valacyclovir?

Valacyclovir has active ingredients of valacyclovir hydrochloride. It is often used in genital herpes. eHealthMe is studying from 42,107 Valacyclovir users. Check the latest studies of Valacyclovir.

What is Sporanox?

Sporanox has active ingredients of itraconazole. It is often used in fungal infection. eHealthMe is studying from 6,137 Sporanox users. Check the latest studies of Sporanox.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 16, 2026

18 people who take Valacyclovir and Sporanox together, and have interactions are studied.

Valacyclovir and Sporanox drug interactions.

What are the common drug interactions of Valacyclovir and Sporanox, by gender? *:

female:

Immunosuppressant drug level increased
Anaemia (lack of blood)
Epstein-barr virus associated lymphoma (epstein-barr virus associated tumour)
Headache (pain in head)
Hypertension (high blood pressure)
Nausea (feeling of having an urge to vomit)
Renal failure (kidney dysfunction)
Thrombotic microangiopathy (a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury)
Sepsis (a severe blood infection that can lead to organ failure and death)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)

male:

Septic shock (shock due to blood infection)
Coma (state of unconsciousness lasting more than six hours)
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arthralgia (joint pain)
Atelectasis (partial or complete collapse of the lung)
Back pain
Bone density decreased
Breath sounds

What are the common drug interactions of Valacyclovir and Sporanox, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Immunosuppressant drug level increased
Anaemia (lack of blood)
Epstein-barr virus associated lymphoma (epstein-barr virus associated tumour)
Renal failure (kidney dysfunction)
Thrombotic microangiopathy (a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Encephalitis (inflammation of the brain)
Headache (pain in head)
Hypertension (high blood pressure)
Nausea (feeling of having an urge to vomit)

30-39:

Coma (state of unconsciousness lasting more than six hours)
Renal insufficiency (insufficient excretion of wastes by the kidneys)
Cerebral ischaemia (insufficient blood flow to the brain to meet metabolic demand)
Urinary retention (the inability to completely or partially empty the bladder)

40-49:

Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arthralgia (joint pain)
Bone density decreased
Chronic kidney disease
Emotional distress
Gait disturbance
Malaise (a feeling of general discomfort or uneasiness)
Mobility decreased (ability to move is reduced)

50-59:

Sepsis (a severe blood infection that can lead to organ failure and death)

60+:

Organising pneumonia (pathologically by the presence in the distal air spaces of buds of granulation tissue)
Pneumonia
Septic shock (shock due to blood infection)

What are the existing conditions these people have? *

Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 4 people, 22.22%
Hiv Infection: 2 people, 11.11%
Rashes (redness): 1 person, 5.56%
Blood Calcium Increased: 1 person, 5.56%
Cytokine Release Syndrome (immediate complication occurring with the use of anti-t cell antibody infusions): 1 person, 5.56%
Diarrhea: 1 person, 5.56%
Diffuse Large B-Cell Lymphoma Stage Ii (cancer of b cells, a type of white blood cell-stage ii): 1 person, 5.56%
Fluid Retention (an abnormal accumulation of fluid in the blood): 1 person, 5.56%
Herpes Zoster: 1 person, 5.56%
High Blood Pressure: 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Valacyclovir and Sporanox?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously