Valerian and Hydroxyzine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Valerian (valerian) and Hydroxyzine (hydroxyzine hydrochloride). Common drug interactions include suicide attempt among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Valerian and Hydroxyzine. It is created by eHealthMe based on reports of 29 people who take the same drugs from the FDA, and is updated regularly.

What is Valerian?

Valerian has active ingredients of valerian. It is often used in insomnia. eHealthMe is studying from 1,271 Valerian users. Check the latest studies of Valerian.

What is Hydroxyzine?

Hydroxyzine has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 54,070 Hydroxyzine users. Check the latest studies of Hydroxyzine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

29 people who take Valerian and Hydroxyzine together, and have interactions are studied.

Valerian and Hydroxyzine drug interactions.

What are the common drug interactions of Valerian and Hydroxyzine, by gender? *:

female:

Suicide attempt
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Liver injury
Abortion spontaneous (naturally occurring miscarriage)
Arthralgia (joint pain)
Asthma
Attention deficit hyperactivity disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness)
Balance disorder
Dizziness
Drug abuse

male:

Drug ineffective
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Carotid artery occlusion (artery blockage)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Colitis microscopic (inflammation of colon with diarrhoea and abdominal cramps)
Cough
Decreased activity
Decreased appetite
Decreased interest
Depression

What are the common drug interactions of Valerian and Hydroxyzine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Suicide attempt
Drug abuse

30-39:

Asthma
Attention deficit hyperactivity disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness)
Dizziness
Muscular weakness (muscle weakness)

40-49:

Abortion spontaneous (naturally occurring miscarriage)
Maternal exposure during pregnancy (use of substance during pregnancy)
Suicide attempt

50-59:

Liver injury
Arthralgia (joint pain)
Haematoma (collection of blood outside the blood vessels)
Hepatic enzyme increased
Hepatocellular injury (liver injury)
Injection site pain
Injection site reaction

60+:

Drug ineffective
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Blood pressure increased
Cardiac disorder
Carotid artery occlusion (artery blockage)
Colitis microscopic (inflammation of colon with diarrhoea and abdominal cramps)
Cough
Decreased activity
Decreased appetite
Decreased interest

What are the existing conditions these people have? *

High Blood Pressure: 3 people, 10.34%
High Blood Cholesterol: 2 people, 6.90%
Cardiac Disorder: 2 people, 6.90%
Chest Pain: 2 people, 6.90%
Constipation: 2 people, 6.90%
Diabetes: 2 people, 6.90%
Dizziness: 2 people, 6.90%
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs): 2 people, 6.90%
Renal Disorder (kidney disease): 2 people, 6.90%
Rashes (redness): 2 people, 6.90%

* Approximation only. Some reports may have incomplete information.

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