Valerian and Restasis drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Valerian (valerian) and Restasis (cyclosporine). Common drug interactions include diarrhoea among females and femur fracture among males.
The phase IV clinical study analyzes what interactions people have when they take Valerian and Restasis. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.
What is Valerian?
Valerian has active ingredients of valerian. It is often used in insomnia. eHealthMe is studying from 1,271 Valerian users. Check the latest studies of Valerian.
What is Restasis?
Restasis has active ingredients of cyclosporine. It is often used in dry eyes. eHealthMe is studying from 35,199 Restasis users. Check the latest studies of Restasis.
eHealthMe: drug outcomes in the real world
eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.
17 people who take Valerian and Restasis together, and have interactions are studied.

What are the common drug interactions of Valerian and Restasis, by gender? *:
female:
- Diarrhoea
- Cataract (clouding of the lens inside the eye)
- Catheter site erythema (redness of skin at catheter site)
- Rash
- Contusion (a type of hematoma of tissue in which capillaries)
- Fatigue (feeling of tiredness)
- Infusion site pain
- Abdominal pain upper
- Constipation
- Erythema (redness of the skin)
male:
- Femur fracture
- Hip fracture
- Hypotension (abnormally low blood pressure)
- Increased upper airway secretion
- Joint injury
- Joint swelling
- Lower respiratory tract infection
- Mucosal discolouration (change in colour of mucosal membrane)
- Rehabilitation therapy
- Scapula fracture (a fracture of the scapula, the shoulder blade)
What are the common drug interactions of Valerian and Restasis, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
n/a
30-39:
- Drug ineffective
- Eye discharge
- Eye irritation
- Foreign body sensation in eyes (feeling of something in eye)
- Ocular hyperaemia (an abnormally large amount of blood in eye)
- Photophobia (extreme sensitivity to light)
- Pruritus (severe itching of the skin)
- Vision blurred
40-49:
n/a
50-59:
- Fatigue (feeling of tiredness)
- Hyperhidrosis (abnormally increased sweating)
- Malaise (a feeling of general discomfort or uneasiness)
- Memory impairment
- Migraine (headache)
60+:
- Diarrhoea
- Cataract (clouding of the lens inside the eye)
- Femur fracture
- Hereditary angioedema (recurrent episodes of severe swelling)
- Hip fracture
- Hypersensitivity
- Joint swelling
- Nodule (a growth of abnormal tissue)
- Pneumonia
- Pyrexia (fever)
What are the existing conditions these people have? *
- Polymyositis (inflammatory muscle disease that causes weakness of the skeletal muscles): 4 people, 23.53%
- Parkinson's Disease: 4 people, 23.53%
- Myasthenia Gravis (a chronic condition that causes muscles to tire and weaken easily): 4 people, 23.53%
- Immune System Disorder: 4 people, 23.53%
- Sleep Disorder: 2 people, 11.76%
- Urinary Tract Infection: 1 person, 5.88%
- Thrombosis (formation of a blood clot inside a blood vessel): 1 person, 5.88%
- Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 5.88%
- Pneumonia: 1 person, 5.88%
- Migraine Without Aura (headache without neurological problems): 1 person, 5.88%
* Approximation only. Some reports may have incomplete information.
Do you take Valerian and Restasis?
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Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Valerian and Restasis:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Valerian:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Restasis:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Valerian and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Restasis and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- O’Brien FE, O’Connor RM, Clarke G, Donovan MD, Dinan TG, Griffin BT, Cryan JF, "The P-glycoprotein inhibitor cyclosporin A differentially influences behavioural and neurochemical responses to the antidepressant escitalopram", Behavioural brain research, 2014 Mar .
- O’Brien FE, O’Connor RM, Clarke G, Donovan MD, Dinan TG, Griffin BT, Cryan JF, "The P-glycoprotein inhibitor cyclosporin A differentially influences behavioural and neurochemical responses to the antidepressant escitalopram", Behavioural brain research, 2014 Mar .
How the study uses the data?
The study uses data from the FDA. It is based on valerian and cyclosporine (the active ingredients of Valerian and Restasis, respectively), and Valerian and Restasis (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
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