1. Home
  2. Analysis
  3. Valproate-sodium
  4. Entresto

Valproate sodium and Entresto drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Valproate sodium (valproate sodium) and Entresto (sacubitril; valsartan). Common drug interactions include pancreatitis among females and drug-induced liver injury among males.

The phase IV clinical study analyzes what interactions people have when they take Valproate sodium and Entresto. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Valproate sodium?

Valproate sodium has active ingredients of valproate sodium. It is often used in epilepsy. eHealthMe is studying from 24,044 Valproate sodium users. Check the latest studies of Valproate sodium.

What is Entresto?

Entresto has active ingredients of sacubitril; valsartan. eHealthMe is studying from 126,628 Entresto users. Check the latest studies of Entresto.

On Jul, 08, 2026

13 people who take Valproate sodium and Entresto together, and have interactions are studied.

Valproate sodium and Entresto drug interactions.

What are the common drug interactions of Valproate Sodium and Entresto, by gender? *:

female:

  1. Pancreatitis (inflammation of pancreas)
  2. Cardiac failure
  3. Cough
  4. Dyspnoea (difficult or laboured respiration)
  5. Immunodeficiency

male:

  1. Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
  2. Altered state of consciousness (altered state of mind)
  3. Blood creatinine increased
  4. Blood glucose increased
  5. Blood urea increased
  6. Death
  7. Drug level increased
  8. Dysphagia (a condition in which swallowing is difficult or painful)
  9. General physical health deterioration (weak health status)
  10. Glomerular filtration rate decreased

What are the common drug interactions of Valproate Sodium and Entresto, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

  1. Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)

60+:

  1. Pancreatitis (inflammation of pancreas)
  2. Altered state of consciousness (altered state of mind)
  3. General physical health deterioration (weak health status)
  4. Glomerular filtration rate decreased
  5. Immunodeficiency
  6. Blood creatinine increased
  7. Blood glucose increased
  8. Blood urea increased
  9. Cardiac failure
  10. Cough

What are the existing conditions these people have? *

  1. Parkinson's Disease: 6 people, 46.15%
  2. Pain: 6 people, 46.15%
  3. Lung Disorder (lung disease): 6 people, 46.15%
  4. Cardiac Failure: 6 people, 46.15%
  5. Anaemia (lack of blood): 6 people, 46.15%
  6. Itching: 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Valproate sodium and Entresto?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Valproate sodium and Entresto:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Valproate sodium:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Entresto:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Valproate sodium and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Entresto and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on valproate sodium and sacubitril; valsartan (the active ingredients of Valproate sodium and Entresto, respectively), and Valproate sodium and Entresto (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe:

© 2026 eHealthMe.com. All rights reserved. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy.