Valproate sodium and Pemetrexed drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Valproate sodium (valproate sodium) and Pemetrexed (pemetrexed). Common drug interactions include asthenia among females and rheumatoid nodule among males.

The phase IV clinical study analyzes what interactions people have when they take Valproate sodium and Pemetrexed. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Valproate sodium?

Valproate sodium has active ingredients of valproate sodium. It is often used in epilepsy. eHealthMe is studying from 24,044 Valproate sodium users. Check the latest studies of Valproate sodium.

What is Pemetrexed?

Pemetrexed has active ingredients of pemetrexed. eHealthMe is studying from 17,491 Pemetrexed users. Check the latest studies of Pemetrexed.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 18, 2026

11 people who take Valproate sodium and Pemetrexed together, and have interactions are studied.

Valproate sodium and Pemetrexed drug interactions.

What are the common drug interactions of Valproate Sodium and Pemetrexed, by gender? *:

female:

Asthenia (weakness)
Neutropenia (an abnormally low number of neutrophils)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Renal failure (kidney dysfunction)
Swelling face
Thrombocytopenia (decrease of platelets in blood)
Weight increased
C-reactive protein increased
Diarrhoea
Livedo reticularis (a lace-like purplish discoloration of the skin)

male:

Rheumatoid nodule (a local swelling or tissue lump with rheumatoid disease)

What are the common drug interactions of Valproate Sodium and Pemetrexed, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Rheumatoid nodule (a local swelling or tissue lump with rheumatoid disease)

50-59:

Dehydration (dryness resulting from the removal of water)
General physical health deterioration (weak health status)
Neutropenia (an abnormally low number of neutrophils)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Thrombocytopenia (decrease of platelets in blood)
C-reactive protein increased
Diarrhoea
Livedo reticularis (a lace-like purplish discoloration of the skin)
Malaise (a feeling of general discomfort or uneasiness)
Protein c decreased

60+:

Asthenia (weakness)
Fatigue (feeling of tiredness)
Hyperthyroidism (over activity of the thyroid gland)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Liver disorder (liver diseases)
Nephropathy toxic (damage to kidney due to toxins)
Renal failure (kidney dysfunction)
Swelling face
Weight increased

What are the existing conditions these people have? *

Stress And Anxiety: 5 people, 45.45%
Mental Disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 5 people, 45.45%
Insomnia (sleeplessness): 5 people, 45.45%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 5 people, 45.45%
Bronchial Carcinoma (lung cancer): 5 people, 45.45%
Lung Cancer - Non-Small Cell (lung cancer): 4 people, 36.36%
Lung Adenocarcinoma Stage Iv (the cancer has spread to other organs of the body, such as the other lung, brain, or liver): 2 people, 18.18%
Metastases To Central Nervous System (cancer spreads to central nervous system): 1 person, 9.09%
Breast Cancer Metastatic: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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