Valproic acid and Cefuroxime drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Valproic acid (valproic acid) and Cefuroxime (cefuroxime sodium). Common drug interactions include acute circulatory failure among females and erythema among males.

The phase IV clinical study analyzes what interactions people have when they take Valproic acid and Cefuroxime. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Valproic acid?

Valproic acid has active ingredients of valproic acid. It is often used in epilepsy. eHealthMe is studying from 36,193 Valproic acid users. Check the latest studies of Valproic acid.

What is Cefuroxime?

Cefuroxime has active ingredients of cefuroxime sodium. It is often used in sinusitis. eHealthMe is studying from 12,999 Cefuroxime users. Check the latest studies of Cefuroxime.

On Jul, 05, 2026

30 people who take Valproic acid and Cefuroxime together, and have interactions are studied.

Valproic acid and Cefuroxime drug interactions.

What are the common drug interactions of Valproic Acid and Cefuroxime, by gender? *:

female:

Acute circulatory failure (shock)
Adult respiratory distress syndrome (type of lung (pulmonary) failure)
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Arthralgia (joint pain)
Blood carbon dioxide increased
Bone marrow depression (decreased ability or inability of the bone marrow to produce blood cells)
Cerebral infarction (less blood supply to brain resulting tissue damage)
Cerebral oedema (swelling of brain)
Cheilitis (infection of lips)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)

male:

Erythema (redness of the skin)
Hypotension (abnormally low blood pressure)
Urticaria (rash of round, red welts on the skin that itch intensely)
Crepitations (noises are produced by the rubbing of parts one against the other)
Hypertonia (abnormal increase in muscle tension and a reduced ability of a muscle to stretch)
Mycoplasma infection (bacterial infection)
Pallor
Abdominal pain upper
Agitation (state of anxiety or nervous excitement)
Angioedema (rapid swelling of the dermis)

What are the common drug interactions of Valproic Acid and Cefuroxime, by age (0-1 to 60+)? *:

0-1:

Hepatic failure (liver failure)
Laboratory test abnormal
Metabolic disorder (an abnormal function and pattern of body fat. insulin resistance refers to the diminished ability of cells to respond to the action of insulin in promoting the transport of the sugar glucose, from blood into muscles and other tissues)

2-9:

Angioedema (rapid swelling of the dermis)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Bradycardia (abnormally slow heart action)
Brain stem syndrome
Coma (state of unconsciousness lasting more than six hours)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Depressed level of consciousness
Drug ineffective
Drug toxicity
Erythema (redness of the skin)

10-19:

Drug ineffective
Pyrexia (fever)
Crepitations (noises are produced by the rubbing of parts one against the other)
Hypertonia (abnormal increase in muscle tension and a reduced ability of a muscle to stretch)
Mycoplasma infection (bacterial infection)
Pallor
Acute circulatory failure (shock)
Cerebral infarction (less blood supply to brain resulting tissue damage)
Cerebral oedema (swelling of brain)
Disseminated intravascular coagulation (systemic activation of blood coagulation)

20-29:

Drug effect decreased
Ileus paralytic (obstruction of the intestine due to paralysis of the intestinal muscles)
Maternal exposure during pregnancy (use of substance during pregnancy)
Pregnancy
Premature delivery

30-39:

Renal failure acute (rapid kidney dysfunction)
Suicide attempt

40-49:

Haematoma (collection of blood outside the blood vessels)
International normalised ratio increased
Petechiae (a small red or purple spot caused by bleeding into the skin)
Skin necrosis (skin damage)
Therapeutic response decreased (less preventive response)
Adult respiratory distress syndrome (type of lung (pulmonary) failure)
Blood carbon dioxide increased
Coma (state of unconsciousness lasting more than six hours)
Confusion
Depression

50-59:

Abdominal pain
Abdominal pain upper
Agitation (state of anxiety or nervous excitement)
Anxiety
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Depression
Diarrhoea
Dizziness
Fatigue (feeling of tiredness)
Fibromyalgia (a long-term condition which causes pain all over the body)

60+:

Erythema (redness of the skin)
Dizziness
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Arthralgia (joint pain)
Asthenia (weakness)
Blood pressure decreased
Bone marrow depression (decreased ability or inability of the bone marrow to produce blood cells)
C-reactive protein increased
Cheilitis (infection of lips)
Colonic polyp (extra part of colon tissue grow in intestine)

What are the existing conditions these people have? *

Urticaria (rash of round, red welts on the skin that itch intensely): 3 people, 10.00%
Nervous System Disorder (a general class of medical conditions affecting the nervous system): 3 people, 10.00%
Infection: 3 people, 10.00%
Conjunctivitis (pink eye): 3 people, 10.00%
Pneumonia: 2 people, 6.67%
Pain: 2 people, 6.67%
Heart Disease: 2 people, 6.67%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 2 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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