Valproic acid and Colace drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Valproic acid (valproic acid) and Colace (docusate ). Common drug interactions include asthenia among females and lactic acidosis among males.

The phase IV clinical study analyzes what interactions people have when they take Valproic acid and Colace. It is created by eHealthMe based on reports of 57 people who take the same drugs from the FDA, and is updated regularly.

What is Valproic acid?

Valproic acid has active ingredients of valproic acid. It is often used in epilepsy. eHealthMe is studying from 36,193 Valproic acid users. Check the latest studies of Valproic acid.

What is Colace?

Colace has active ingredients of docusate . It is often used in constipation. eHealthMe is studying from 41,841 Colace users. Check the latest studies of Colace.

On Jul, 20, 2026

57 people who take Valproic acid and Colace together, and have interactions are studied.

Valproic acid and Colace drug interactions.

What are the common drug interactions of Valproic Acid and Colace, by gender? *:

female:

Asthenia (weakness)
Cellulitis (infection under the skin)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Decreased appetite
Depression
Diarrhoea
Drug abuse
Hemiparesis (weakness on one side of the body)
Influenza
Suicide attempt

male:

Lactic acidosis (low ph in body tissues)
Dehydration (dryness resulting from the removal of water)
Sepsis (a severe blood infection that can lead to organ failure and death)
Vomiting
Abdominal pain
Delirium (wild excitement)
Nonspecific reaction (unspecified reaction)
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haematemesis (vomiting of blood)

What are the common drug interactions of Valproic Acid and Colace, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Decreased appetite
Influenza
Weight decreased
Acute respiratory failure
Pneumonia
Status epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure)
Viral infection

10-19:

Hypersomnia (excessive daytime sleepiness (eds))
Abdominal discomfort
Diarrhoea
Nausea (feeling of having an urge to vomit)
Adverse drug reaction
Hypophagia (reduced food intake)

20-29:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Injury
Pain
Drug ineffective
Electrocardiogram abnormal
Nodal arrhythmia (an irregular heart beat originating from within the atrioventricular node)

30-39:

Lactic acidosis (low ph in body tissues)
Unresponsive to stimuli
Dizziness
Vomiting
Abdominal pain
Agitation (state of anxiety or nervous excitement)
Blood pressure decreased
Death
Dehydration (dryness resulting from the removal of water)
Renal failure (kidney dysfunction)

40-49:

Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Pyrexia (fever)
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
Abdominal discomfort
Anaemia (lack of blood)
Blood thyroid stimulating hormone increased
Chronic lymphocytic leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell))
Confusional state
Consciousness fluctuating

50-59:

Abdominal sepsis (abdominal infection)
Neutropenia (an abnormally low number of neutrophils)
Pulmonary embolism (blockage of the main artery of the lung)
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
Fall
Sepsis (a severe blood infection that can lead to organ failure and death)
Abdominal distension
Blood pressure decreased
Delirium (wild excitement)
Diarrhoea

60+:

Hypotension (abnormally low blood pressure)
Hallucination (an experience involving the perception of something not present)
Cellulitis (infection under the skin)
Death
Pneumonia
Sepsis (a severe blood infection that can lead to organ failure and death)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Urinary tract infection
Anger
Gastric polyps (abnormal growth of stomach tissue projecting from a mucous membrane)

What are the existing conditions these people have? *

Pain: 10 people, 17.54%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 5 people, 8.77%
High Blood Pressure: 5 people, 8.77%
Agitation (state of anxiety or nervous excitement): 5 people, 8.77%
Pulmonary Embolism (blockage of the main artery of the lung): 4 people, 7.02%
Ovarian Cancer (cancer of ovary): 4 people, 7.02%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 3 people, 5.26%
Parkinson's Disease: 3 people, 5.26%
Nausea (feeling of having an urge to vomit): 3 people, 5.26%
Insomnia (sleeplessness): 3 people, 5.26%

* Approximation only. Some reports may have incomplete information.

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