Valproic acid and Diphenhydramine hydrochloride drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Valproic acid (valproic acid) and Diphenhydramine hydrochloride (diphenhydramine hydrochloride). Common drug interactions include death among females and completed suicide among males.

The phase IV clinical study analyzes what interactions people have when they take Valproic acid and Diphenhydramine hydrochloride. It is created by eHealthMe based on reports of 48 people who take the same drugs from the FDA, and is updated regularly.

What is Valproic acid?

Valproic acid has active ingredients of valproic acid. It is often used in epilepsy. eHealthMe is studying from 36,193 Valproic acid users. Check the latest studies of Valproic acid.

What is Diphenhydramine hydrochloride?

Diphenhydramine hydrochloride has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 26,097 Diphenhydramine hydrochloride users. Check the latest studies of Diphenhydramine hydrochloride.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

48 people who take Valproic acid and Diphenhydramine hydrochloride together, and have interactions are studied.

Valproic acid and Diphenhydramine hydrochloride drug interactions.

What are the common drug interactions of Valproic Acid and Diphenhydramine Hydrochloride, by gender? *:

female:

Death
Delusion (a false belief or opinion)
Depressed mood
Dizziness
Ear infection
Emotional distress
Fatigue (feeling of tiredness)
Generalised anxiety disorder (excessive, uncontrollable, unexplained and often irrational worry)
Haematoma (collection of blood outside the blood vessels)
Hallucination, auditory (perceiving sounds without auditory stimulus)

male:

Completed suicide (act of taking one's own life)
Aggression
Coma (state of unconsciousness lasting more than six hours)
Compartment syndrome (painful condition that occurs when pressure within the muscles builds to dangerous levels)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Electrocardiogram qrs complex prolonged
Hepatic enzyme increased
Hyperkalaemia (damage to or disease of the kidney)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Anxiety

What are the common drug interactions of Valproic Acid and Diphenhydramine Hydrochloride, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Hypersomnia (excessive daytime sleepiness (eds))
Aggression
Psychomotor hyperactivity (feelings of extreme restlessness)
Bezoar (mass found trapped in the gastrointestinal system)
Gastrointestinal obstruction
Intestinal obstruction
Vomiting
Apnoea (suspension of external breathing)
Drug ineffective
Headache (pain in head)

20-29:

Overdose
Aggression
Delirium (wild excitement)
Psoriasis (immune-mediated disease that affects the skin)
Staphylococcal bacteraemia (a bacterial infection of blood)
Staphylococcal infection (an infection with staphylococcus bacteria)

30-39:

Acidosis (build-up of carbon dioxide in the blood)
Blood creatine phosphokinase increased
Brain injury
Coma (state of unconsciousness lasting more than six hours)
Compartment syndrome (painful condition that occurs when pressure within the muscles builds to dangerous levels)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Electrocardiogram qrs complex prolonged
Hepatic enzyme increased
Hyperkalaemia (damage to or disease of the kidney)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)

40-49:

Completed suicide (act of taking one's own life)
Anxiety
Cardiac arrest
Choking (mechanical obstruction of the flow of air from the environment into the lungs)
Chronic kidney disease
Dizziness
Emotional distress
Fatigue (feeling of tiredness)
Hypoxic-ischaemic encephalopathy (a condition that occurs when the entire brain is deprived of an adequate oxygen supply, but the deprivation isn't total)
Nephrolithiasis (calculi in the kidneys)

50-59:

Laryngeal oedema (swelling of larynx)
Coma (state of unconsciousness lasting more than six hours)
Depressed level of consciousness
Hypotension (abnormally low blood pressure)
Tremor (trembling or shaking movements in one or more parts of your body)
Clonus (series of involuntary, rhythmic, muscular contractions and relaxations)
Completed suicide (act of taking one's own life)
Death
Ischaemia (insufficient supply of blood to an organ, usually due to a blocked artery)
Anticholinergic syndrome (absolute or relative reduction in cholinergic activity in the central nervous system)

60+:

Delirium (wild excitement)
Asthmatic crisis
Influenza
Intentional self-injury
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Psychotic disorder
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Accidental death
Acute generalised exanthematous pustulosis (acute febrile drug eruption)
Agitation (state of anxiety or nervous excitement)

What are the existing conditions these people have? *

Seizures (abnormal excessive or synchronous neuronal activity in the brain): 5 people, 10.42%
Agitation (state of anxiety or nervous excitement): 5 people, 10.42%
Stress And Anxiety: 3 people, 6.25%
Pain: 3 people, 6.25%
Movement - Uncontrolled Or Slow: 3 people, 6.25%
Hypersensitivity: 3 people, 6.25%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 6.25%
Diarrhea: 3 people, 6.25%
Depression: 3 people, 6.25%
Aggression: 3 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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