Valproic acid and Maxalt drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Valproic acid (valproic acid) and Maxalt (rizatriptan benzoate). Common drug interactions include cough among females and drug abuse among males.
The phase IV clinical study analyzes what interactions people have when they take Valproic acid and Maxalt. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.
What is Valproic acid?
Valproic acid has active ingredients of valproic acid. It is often used in epilepsy. eHealthMe is studying from 36,193 Valproic acid users. Check the latest studies of Valproic acid.
What is Maxalt?
Maxalt has active ingredients of rizatriptan benzoate. It is often used in migraine. eHealthMe is studying from 12,754 Maxalt users. Check the latest studies of Maxalt.
26 people who take Valproic acid and Maxalt together, and have interactions are studied.

What are the common drug interactions of Valproic Acid and Maxalt, by gender? *:
female:
- Cough
- Diarrhoea
- Weight decreased
- Abdominal pain
- Anuria (failure of the kidneys to produce urine)
- Dyspepsia (indigestion)
- Dyspnoea (difficult or laboured respiration)
- Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
- Nausea (feeling of having an urge to vomit)
- Neovascularisation (development of tiny, abnormal, leaky blood vessels inside the eye)
male:
- Drug abuse
- Insomnia (sleeplessness)
- Mouth ulceration (mouth ulcers)
- Myopathy (a muscular disease in which the muscle fibres do not function)
- Myopathy toxic (a muscular disease in which the muscle fibres do not function due to toxin)
- Neuropathy peripheral (surface nerve damage)
- Oxygen saturation decreased
- Pain
- Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
- Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)
What are the common drug interactions of Valproic Acid and Maxalt, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
- Back injury
- Depression
- Fall
- Gastrointestinal disorder (functional problems of gastrointestinal tract)
- Growth hormone deficiency
- Hospitalisation
- Mouth ulceration (mouth ulcers)
- Myopathy (a muscular disease in which the muscle fibres do not function)
- Myopathy toxic (a muscular disease in which the muscle fibres do not function due to toxin)
- Neuropathy peripheral (surface nerve damage)
20-29:
n/a
30-39:
- Hypersensitivity
40-49:
- Memory impairment
- Depression
- Ovarian enlargement
- Pelvic peritoneal adhesions
- Haemoperitoneum (presence of blood in the peritoneal cavity)
- Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
- Pelvic pain
- Personality change
- Fatigue (feeling of tiredness)
- Flat affect (absence of emotional response to a situation)
50-59:
- Asthma
- Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
- Cystitis interstitial (unknown cause characterized by bladder pain)
- Inflammation
- Abdominal pain
- Anuria (failure of the kidneys to produce urine)
- Cough
- Diarrhoea
- Drug ineffective
- Dyspepsia (indigestion)
60+:
- Abdominal pain
- Anuria (failure of the kidneys to produce urine)
- Weight decreased
- Drug ineffective
- Cough
- Diarrhoea
- Dyspepsia (indigestion)
- Dyspnoea (difficult or laboured respiration)
- Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
- Nausea (feeling of having an urge to vomit)
What are the existing conditions these people have? *
- Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 8 people, 30.77%
- Nausea (feeling of having an urge to vomit): 5 people, 19.23%
- Drowsiness: 3 people, 11.54%
- Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 11.54%
* Approximation only. Some reports may have incomplete information.
Do you take Valproic acid and Maxalt?
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Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
- Valproic acid (36,193 reports)
- Maxalt (12,754 reports)
Browse all drug interactions of Valproic acid and Maxalt:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Valproic acid:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Maxalt:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Valproic acid and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Maxalt and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Gupta E, Kunjal R, Cury JD, "Severe hyponatremia due to valproic acid toxicity", Journal of clinical medicine research, 2015 Jan .
- Hwabejire JO, Lu J, Liu B, Li Y, Halaweish I, Alam HB, "Valproic acid for the treatment of hemorrhagic shock: a dose-optimization study", journal of surgical research, 2014 Jan .
- Gupta E, Kunjal R, Cury JD, "Severe hyponatremia due to valproic acid toxicity", Journal of clinical medicine research, 2015 Jan .
- Hwabejire JO, Lu J, Liu B, Li Y, Halaweish I, Alam HB, "Valproic acid for the treatment of hemorrhagic shock: a dose-optimization study", journal of surgical research, 2014 Jan .
How the study uses the data?
The study uses data from the FDA. It is based on valproic acid and rizatriptan benzoate (the active ingredients of Valproic acid and Maxalt, respectively), and Valproic acid and Maxalt (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
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