Valproic acid and Prochlorperazine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Valproic acid (valproic acid) and Prochlorperazine (prochlorperazine). Common drug interactions include drug ineffective among females and completed suicide among males.

The phase IV clinical study analyzes what interactions people have when they take Valproic acid and Prochlorperazine. It is created by eHealthMe based on reports of 64 people who take the same drugs from the FDA, and is updated regularly.

What is Valproic acid?

Valproic acid has active ingredients of valproic acid. It is often used in epilepsy. eHealthMe is studying from 36,193 Valproic acid users. Check the latest studies of Valproic acid.

What is Prochlorperazine?

Prochlorperazine has active ingredients of prochlorperazine. It is often used in nausea. eHealthMe is studying from 14,632 Prochlorperazine users. Check the latest studies of Prochlorperazine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

64 people who take Valproic acid and Prochlorperazine together, and have interactions are studied.

Valproic acid and Prochlorperazine drug interactions.

What are the common drug interactions of Valproic Acid and Prochlorperazine, by gender? *:

female:

Drug ineffective
Abdominal pain
Anuria (failure of the kidneys to produce urine)
Cough
Diarrhoea
Dyspepsia (indigestion)
Dyspnoea (difficult or laboured respiration)
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Neovascularisation (development of tiny, abnormal, leaky blood vessels inside the eye)
Paradoxical drug reaction

male:

Completed suicide (act of taking one's own life)
Agitation (state of anxiety or nervous excitement)
Aggression
Blood creatine phosphokinase increased
Fatigue (feeling of tiredness)
Hypokalaemia (low potassium)
Maternal exposure during pregnancy (use of substance during pregnancy)
Vomiting
Muscle rigidity (muscle stiffness)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)

What are the common drug interactions of Valproic Acid and Prochlorperazine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Agitation (state of anxiety or nervous excitement)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents)
Hyperthermia (body temperature greatly above normal)
Aggression
Cardiac disorder
Hypokalaemia (low potassium)
Type 1 diabetes mellitus
Vomiting
Muscle rigidity (muscle stiffness)

30-39:

Completed suicide (act of taking one's own life)
Abdominal discomfort
Blood pressure decreased
Body temperature increased
Death
Decreased appetite
Diarrhoea
Fatigue (feeling of tiredness)
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Viral upper respiratory tract infection

40-49:

Coma (state of unconsciousness lasting more than six hours)
Blood creatine phosphokinase increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiac disorder
Cardiac failure congestive
Dehydration (dryness resulting from the removal of water)
Fatigue (feeling of tiredness)
Oedema peripheral (superficial swelling)
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Pain

50-59:

Abdominal pain
Anuria (failure of the kidneys to produce urine)
Cough
Diarrhoea
Drug ineffective
Dyspepsia (indigestion)
Dyspnoea (difficult or laboured respiration)
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Neovascularisation (development of tiny, abnormal, leaky blood vessels inside the eye)
Paradoxical drug reaction

60+:

Drug ineffective
Abdominal pain
Weight decreased
Fanconi syndrome acquired (self developed genetic disease of kidney damage due to defective transport system)
Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood)
Ataxia (loss of full control of bodily movements)
Confusion
Drug level increased
Dysarthria (speech disorder)
Dyskinesia (abnormality or impairment of voluntary movement)

What are the existing conditions these people have? *

Migraine (headache): 27 people, 42.19%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 4 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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