Ramelteon and Valproic acid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ramelteon (ramelteon) and Valproic acid (valproic acid). Common drug interactions include bipolar i disorder among females and cardiac arrest among males.

The phase IV clinical study analyzes what interactions people have when they take Ramelteon and Valproic acid. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Ramelteon?

Ramelteon has active ingredients of ramelteon. It is often used in insomnia. eHealthMe is studying from 1,387 Ramelteon users. Check the latest studies of Ramelteon.

What is Valproic acid?

Valproic acid has active ingredients of valproic acid. It is often used in epilepsy. eHealthMe is studying from 36,193 Valproic acid users. Check the latest studies of Valproic acid.

On Apr, 25, 2026

16 people who take Ramelteon and Valproic acid together, and have interactions are studied.

Ramelteon and Valproic acid drug interactions.

What are the common drug interactions of Ramelteon and Valproic Acid, by gender? *:

female:

Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode)
Complex partial seizures (epileptic seizure)
Dissociative identity disorder
Drug detoxification
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
General physical health deterioration (weak health status)
Hypophagia (reduced food intake)
Hypotension (abnormally low blood pressure)
Lethargy (tiredness)

male:

Cardiac arrest
Completed suicide (act of taking one's own life)
Self injurious behaviour
Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Drug abuse
Drug clearance increased
Drug level decreased
Drug toxicity
Heart transplant rejection

What are the common drug interactions of Ramelteon and Valproic Acid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Cardiac arrest
Heart transplant rejection
Poisoning
Self injurious behaviour
Completed suicide (act of taking one's own life)
Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode)
Drug abuse
Drug clearance increased

30-39:

Mania (a state of abnormally elevated or irritable mood)

40-49:

n/a

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Sleep Disorder: 1 person, 6.25%
Salivary Hypersecretion (excess saliva secretion): 1 person, 6.25%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 1 person, 6.25%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 1 person, 6.25%
Borderline Personality Disorder: 1 person, 6.25%
Bipolar I Disorder (mood disorder that is characterized by at least one manic or mixed episode): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

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