Valproic acid and Sirolimus drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Valproic acid (valproic acid) and Sirolimus (sirolimus). Common drug interactions include melas syndrome among females and adenovirus infection among males.

The phase IV clinical study analyzes what interactions people have when they take Valproic acid and Sirolimus. It is created by eHealthMe based on reports of 36 people who take the same drugs from the FDA, and is updated regularly.

What is Valproic acid?

Valproic acid has active ingredients of valproic acid. It is often used in epilepsy. eHealthMe is studying from 36,193 Valproic acid users. Check the latest studies of Valproic acid.

What is Sirolimus?

Sirolimus has active ingredients of sirolimus. eHealthMe is studying from 11,823 Sirolimus users. Check the latest studies of Sirolimus.

On Jul, 20, 2026

36 people who take Valproic acid and Sirolimus together, and have interactions are studied.

Valproic acid and Sirolimus drug interactions.

What are the common drug interactions of Valproic Acid and Sirolimus, by gender? *:

female:

Melas syndrome (melas (myopathy, encephalopathy, lactic acidosis, and stroke-like episodes) is a progressive neurodegenerative disorder)
Mitochondrial toxicity (a condition in which the mitochondria of a body's cells become damaged or decline significantly in number;)
Abdominal discomfort
Blood cholesterol increased
Blood triglycerides increased
Chest discomfort
Decreased appetite
Disease progression
Status migrainosus (a migraine headache for 72 hours)
Stupor (lack of critical cognitive function and level of consciousness)

male:

Adenovirus infection
Aplastic anaemia (blood disorder in which the body's bone marrow doesn't make enough new blood cells)
Epistaxis (bleed from the nose)
Lip haemorrhage (bleeding lip)
Respiratory distress (difficulty in breathing)
Stomatitis (inflammation of mucous membrane of mouth)
Hyperammonaemic encephalopathy (excess of ammonia in the blood, disorder or disease of the brain)
Completed suicide (act of taking one's own life)
Drug ineffective
Anticonvulsant drug level increased

What are the common drug interactions of Valproic Acid and Sirolimus, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Adenovirus infection
Aplastic anaemia (blood disorder in which the body's bone marrow doesn't make enough new blood cells)
Epistaxis (bleed from the nose)
Lip haemorrhage (bleeding lip)
Respiratory distress (difficulty in breathing)
Stomatitis (inflammation of mucous membrane of mouth)

10-19:

Drug ineffective

20-29:

Disease progression

30-39:

Decreased appetite
Status migrainosus (a migraine headache for 72 hours)
Abdominal discomfort
Blood cholesterol increased
Blood triglycerides increased
Chest discomfort

40-49:

Hyperammonaemic encephalopathy (excess of ammonia in the blood, disorder or disease of the brain)

50-59:

Melas syndrome (melas (myopathy, encephalopathy, lactic acidosis, and stroke-like episodes) is a progressive neurodegenerative disorder)
Mitochondrial toxicity (a condition in which the mitochondria of a body's cells become damaged or decline significantly in number;)
Stupor (lack of critical cognitive function and level of consciousness)

60+:

Completed suicide (act of taking one's own life)
Anticonvulsant drug level increased

What are the existing conditions these people have? *

Type 2 Diabetes: 5 people, 13.89%
Immunodeficiency Disorders: 4 people, 11.11%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 4 people, 11.11%
Status Epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure): 3 people, 8.33%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 3 people, 8.33%
Stress And Anxiety: 2 people, 5.56%
Status Migrainosus (a migraine headache for 72 hours): 2 people, 5.56%
Partial Seizures (seizures which affect only a part of the brain at onset): 2 people, 5.56%
Hypersensitivity: 2 people, 5.56%
Headache (pain in head): 2 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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