Valproic acid and Zarontin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Valproic acid (valproic acid) and Zarontin (ethosuximide). Common drug interactions include oedema peripheral among females and nephritis sle among males.

The phase IV clinical study analyzes what interactions people have when they take Valproic acid and Zarontin. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Valproic acid?

Valproic acid has active ingredients of valproic acid. It is often used in epilepsy. eHealthMe is studying from 36,193 Valproic acid users. Check the latest studies of Valproic acid.

What is Zarontin?

Zarontin has active ingredients of ethosuximide. It is often used in petit mal seizure. eHealthMe is studying from 987 Zarontin users. Check the latest studies of Zarontin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Jul, 04, 2026

30 people who take Valproic acid and Zarontin together, and have interactions are studied.

Valproic acid and Zarontin drug interactions.

What are the common drug interactions of Valproic Acid and Zarontin, by gender? *:

female:

Oedema peripheral (superficial swelling)
Acute pulmonary oedema (sudden deposit of fluid in the lung))
Mitral valve disease (disease of mitral valve of heart)
Myocarditis (inflammation of heart muscle myocardium)
Decreased appetite
Acute hepatic failure
Adverse drug reaction
Hospitalisation
Hyperthermia malignant (disease passed down through families that causes a fast rise in body temperature (fever) and severe muscle contractions)
Nausea (feeling of having an urge to vomit)

male:

Nephritis sle (an inflammation of the kidney caused by systemic lupus erythematosus (sle), a disease of the immune system)
Speech disorder
Productive cough
Proteinuria present
Renal disorder (kidney disease)
Skin papilloma (a general medical term for a tumour of the skin or mucous membrane with finger-like projections)
Thrombocytopenia (decrease of platelets in blood)
Tonic clonic movements (generalized seizure that affects the entire brain)
Tooth discolouration (a change in colour of teeth)
Agitation (state of anxiety or nervous excitement)

What are the common drug interactions of Valproic Acid and Zarontin, by age (0-1 to 60+)? *:

0-1:

Decreased appetite
Gait disturbance
Insomnia (sleeplessness)
Irritability
Speech disorder

2-9:

Acute hepatic failure
Hyperthermia malignant (disease passed down through families that causes a fast rise in body temperature (fever) and severe muscle contractions)
Nephritis sle (an inflammation of the kidney caused by systemic lupus erythematosus (sle), a disease of the immune system)
Renal failure acute (rapid kidney dysfunction)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Status epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure)
Tooth discolouration (a change in colour of teeth)
Asthenia (weakness)
Bacterial test positive
Coombs direct test positive

10-19:

Adverse drug reaction
Decreased appetite
Hospitalisation
Nausea (feeling of having an urge to vomit)
Petit mal epilepsy (absence seizure)
Weight decreased

20-29:

Agitation (state of anxiety or nervous excitement)
Tonic clonic movements (generalized seizure that affects the entire brain)

30-39:

Acute pulmonary oedema (sudden deposit of fluid in the lung))
Mitral valve disease (disease of mitral valve of heart)
Myocarditis (inflammation of heart muscle myocardium)
Oedema peripheral (superficial swelling)
Priapism (prolonged and painful erection that can last from several hours up to a few days)

40-49:

n/a

50-59:

Oedema peripheral (superficial swelling)
Phlebitis (inflammation of the walls of a vein)
Venous thrombosis (blood clot (thrombus) that forms within a vein)

60+:

n/a

What are the existing conditions these people have? *

Seizures (abnormal excessive or synchronous neuronal activity in the brain): 6 people, 20.00%
Febrile Convulsion (a convulsion associated with a significant rise in body temperature): 5 people, 16.67%
Encephalopathy (functioning of the brain is affected by some agent or condition): 2 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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