Valsartan and Fiorinal drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Valsartan (valsartan) and Fiorinal (aspirin; butalbital; caffeine). Common drug interactions include spinal fracture among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Valsartan and Fiorinal. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Valsartan?

Valsartan has active ingredients of valsartan. It is often used in high blood pressure. eHealthMe is studying from 63,805 Valsartan users. Check the latest studies of Valsartan.

What is Fiorinal?

Fiorinal has active ingredients of aspirin; butalbital; caffeine. It is often used in migraine. eHealthMe is studying from 2,714 Fiorinal users. Check the latest studies of Fiorinal.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 19, 2026

21 people who take Valsartan and Fiorinal together, and have interactions are studied.

Valsartan and Fiorinal drug interactions.

What are the common drug interactions of Valsartan and Fiorinal, by gender? *:

female:

Spinal fracture (fracture in one of vertebrae)
Breast cancer recurrent
Chondropathy (disease of the cartilage)
Dry eye (lack of adequate tears)
Dry mouth
Fall
Hypotension (abnormally low blood pressure)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Osteoporosis (bones weak and more likely to break)
Therapeutic response unexpected

male:

Death
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Renal injury (kidney injury)
Stress
Arthralgia (joint pain)
Asthenia (weakness)
Anxiety
Emotional distress
Fear
Injury

What are the common drug interactions of Valsartan and Fiorinal, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Death

60+:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Renal injury (kidney injury)
Stress
Arthralgia (joint pain)
Asthenia (weakness)
Breast cancer recurrent
Chondropathy (disease of the cartilage)
Dehydration (dryness resulting from the removal of water)
Diarrhoea

What are the existing conditions these people have? *

Headache (pain in head): 7 people, 33.33%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 23.81%
Pain: 4 people, 19.05%
Sleep Disorder: 3 people, 14.29%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 14.29%
Cough: 2 people, 9.52%
Back Pain: 2 people, 9.52%
Bladder Disorder: 2 people, 9.52%
Breast Cancer: 2 people, 9.52%
Cardiac Disorder: 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

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