Vancomycin hydrochloride and Polaramine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vancomycin hydrochloride (vancomycin hydrochloride) and Polaramine (dexchlorpheniramine maleate). Common drug interactions include aspartate aminotransferase increased among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Vancomycin hydrochloride and Polaramine. It is created by eHealthMe based on reports of 91 people who take the same drugs from the FDA, and is updated regularly.

What is Vancomycin hydrochloride?

Vancomycin hydrochloride has active ingredients of vancomycin hydrochloride. It is often used in mrsa infection. eHealthMe is studying from 8,399 Vancomycin hydrochloride users. Check the latest studies of Vancomycin hydrochloride.

What is Polaramine?

Polaramine has active ingredients of dexchlorpheniramine maleate. It is often used in allergic rhinitis. eHealthMe is studying from 10,531 Polaramine users. Check the latest studies of Polaramine.

On Jul, 09, 2026

91 people who take Vancomycin hydrochloride and Polaramine together, and have interactions are studied.

Vancomycin hydrochloride and Polaramine drug interactions.

What are the common drug interactions of Vancomycin Hydrochloride and Polaramine, by gender? *:

female:

Aspartate aminotransferase increased
Hypertension (high blood pressure)
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
Hypokalaemia (low potassium)
Cardiac failure
Febrile neutropenia (fever with reduced white blood cells)
Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
Influenza
Lymphoma (cancer that begins in immune system cells)

male:

Death
Sepsis (a severe blood infection that can lead to organ failure and death)
Hyperammonaemia
Pulmonary interstitial emphysema syndrome (collection of gases outside of the normal air passages and inside the connective tissue of the peribronchovascular sheaths, interlobular septa, and visceral pleura of lungs)
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
Rectal haemorrhage (bleeding from anus)
Restlessness (not able to rest)
Thrombocytopenia (decrease of platelets in blood)
Pyrexia (fever)
Pneumonia

What are the common drug interactions of Vancomycin Hydrochloride and Polaramine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Pyrexia (fever)
Abnormal sensation in eye
Brain herniation (brain herniation is a potentially deadly side effect of very high intracranial pressure that occurs when a part of the brain is squeezed across structures within the skull)
Constipation
Dry skin
Erythema (redness of the skin)
Intracranial tumour haemorrhage (bleeding tumour in brain)
Nausea (feeling of having an urge to vomit)
Pruritus (severe itching of the skin)
Hypertension (high blood pressure)

10-19:

Cerebellar syndrome (impaired blood circulation to cerebellum due to lesion in artery)
Confusional state
Trismus (reduced opening of the jaws)

20-29:

Cardiac failure
Diarrhoea
Febrile neutropenia (fever with reduced white blood cells)
Haemoglobin decreased
Hepatic failure (liver failure)
Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Hypokalaemia (low potassium)
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Oedema (fluid collection in tissue)

30-39:

Rash
Cardiac failure
Catheter related infection
Death
Nasopharyngitis (inflammation of the nasopharynx)
Palpitations (feelings or sensations that your heart is pounding or racing)
Posterior reversible encephalopathy syndrome (posterior reversible encephalopathy syndrome (pres), also known as reversible posterior leukoencephalopathy syndrome (rpls), is a syndrome characterized by headache, confusion, seizures and visual loss)
Pulmonary haemorrhage (acute bleeding from the lung)
Supraventricular tachycardia (rapid heart rhythm originating at or above the atrioventricular node)

40-49:

Hypokalaemia (low potassium)
Lip erosion (peeling off of lip)
Nasopharyngitis (inflammation of the nasopharynx)
Neutropenia (an abnormally low number of neutrophils)
Oedema (fluid collection in tissue)
Oedema peripheral (superficial swelling)
Oral infection
Platelet count decreased
Pneumonia bacterial (pneumonia associated with bacterial infection)
Pneumonia staphylococcal (pneumonia staphylococcal infections are usually caused by the organism staphylococcus aureus)

50-59:

n/a

60+:

Sepsis (a severe blood infection that can lead to organ failure and death)
Death
Hyperammonaemia
Pulmonary interstitial emphysema syndrome (collection of gases outside of the normal air passages and inside the connective tissue of the peribronchovascular sheaths, interlobular septa, and visceral pleura of lungs)
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
Rectal haemorrhage (bleeding from anus)
Restlessness (not able to rest)
Thrombocytopenia (decrease of platelets in blood)
Pneumonia
Hyperglycaemia (high blood sugar)

What are the existing conditions these people have? *

Skin Infection: 39 people, 42.86%
High Blood Pressure: 13 people, 14.29%
Pain: 9 people, 9.89%
Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 8 people, 8.79%
Aplastic Anemia: 7 people, 7.69%
Allergies: 7 people, 7.69%
Constipation: 6 people, 6.59%
Stress And Anxiety: 5 people, 5.49%
Febrile Neutropenia (fever with reduced white blood cells): 5 people, 5.49%
Diabetes: 5 people, 5.49%

* Approximation only. Some reports may have incomplete information.

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