Vancomycin hydrochloride and Xigris drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vancomycin hydrochloride (vancomycin hydrochloride) and Xigris (drotrecogin alfa (activated)). Common drug interactions include activated partial thromboplastin time prolonged among females and cerebral haemorrhage among males.

The phase IV clinical study analyzes what interactions people have when they take Vancomycin hydrochloride and Xigris. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Vancomycin hydrochloride?

Vancomycin hydrochloride has active ingredients of vancomycin hydrochloride. It is often used in mrsa infection. eHealthMe is studying from 8,399 Vancomycin hydrochloride users. Check the latest studies of Vancomycin hydrochloride.

What is Xigris?

Xigris has active ingredients of drotrecogin alfa (activated). eHealthMe is studying from 3,542 Xigris users. Check the latest studies of Xigris.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 15, 2026

18 people who take Vancomycin hydrochloride and Xigris together, and have interactions are studied.

Vancomycin hydrochloride and Xigris drug interactions.

What are the common drug interactions of Vancomycin Hydrochloride and Xigris, by gender? *:

female:

Activated partial thromboplastin time prolonged
International normalised ratio increased
Platelet count decreased
Haematocrit decreased
Haemoglobin decreased
Sepsis (a severe blood infection that can lead to organ failure and death)
Acute respiratory distress syndrome
Arrhythmia (irregular heartbeat)
Asthenia (weakness)
Blood fibrinogen increased

male:

Cerebral haemorrhage (bleeding within the brain)
Staphylococcal sepsis (blood infection by an infection with staphylococcus bacteria)
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)
Staphylococcal bacteraemia (a bacterial infection of blood)
Activated partial thromboplastin time prolonged
Areflexia (absence of a reflex)
Brain death
Colonic polyp (extra part of colon tissue grow in intestine)
Confusional state
Death

What are the common drug interactions of Vancomycin Hydrochloride and Xigris, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Death
Septic embolus (a type of embolism that is infected with bacteria)

30-39:

Activated partial thromboplastin time prolonged
Acute respiratory distress syndrome
Brain death
Cerebral haemorrhage (bleeding within the brain)
Mydriasis (a dilation of the pupil)
Pneumonia
Pulmonary haemorrhage (acute bleeding from the lung)
Respiratory distress (difficulty in breathing)
Thrombocytopenia (decrease of platelets in blood)
Uterine haemorrhage (uterine bleeding)

40-49:

Platelet count decreased
Activated partial thromboplastin time prolonged
Areflexia (absence of a reflex)
Asthenia (weakness)
Cerebral haemorrhage (bleeding within the brain)
Coma (state of unconsciousness lasting more than six hours)
Fibrin d dimer increased
Haemorrhagic cerebral infarction (brain stroke with bleeding)
International normalised ratio decreased
Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)

50-59:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Hepatitis cholestatic (flow of bile from the liver is slowed or blocked)
Pyrexia (fever)
Activated partial thromboplastin time prolonged
Colonic polyp (extra part of colon tissue grow in intestine)
Confusional state
Haemorrhage (bleeding)
Hepatic failure (liver failure)
International normalised ratio increased

60+:

Activated partial thromboplastin time prolonged
International normalised ratio increased
Staphylococcal bacteraemia (a bacterial infection of blood)
Arrhythmia (irregular heartbeat)
Blood fibrinogen increased
Platelet count decreased
Respiratory failure (inadequate gas exchange by the respiratory system)
White blood cell count increased
Staphylococcal sepsis (blood infection by an infection with staphylococcus bacteria)
Haematocrit decreased

What are the existing conditions these people have? *

Sepsis (a severe blood infection that can lead to organ failure and death): 12 people, 66.67%
Septic Shock (shock due to blood infection): 2 people, 11.11%
Toxic Shock Syndrome (a rare but serious medical condition caused by a bacterial infection): 1 person, 5.56%
Multi-Organ Failure (multisystem organ failure): 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

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