Vaniqa and B12 drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vaniqa (eflornithine hydrochloride) and B12 (cobalamin). Common drug interactions include osteitis deformans among females and abdominal adhesions among males.

The phase IV clinical study analyzes what interactions people have when they take Vaniqa and B12. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Vaniqa?

Vaniqa has active ingredients of eflornithine hydrochloride. eHealthMe is studying from 639 Vaniqa users. Check the latest studies of Vaniqa.

What is B12?

B12 has active ingredients of cobalamin. It is often used in vitamin b12 deficiency. eHealthMe is studying from 121,897 B12 users. Check the latest studies of B12.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.



On Aug, 31, 2026

18 people who take Vaniqa and B12 together, and have interactions are studied.

Vaniqa and B12 drug interactions.

What are the common drug interactions of Vaniqa and B12, by gender? *:

female:

  1. Osteitis deformans (a disease of bone occurring in the middle aged and elderly; excessive bone destruction sometimes leading to bone pain)
  2. Pain of skin
  3. Peripheral swelling
  4. Pertussis (whooping cough: a disease of the respiratory mucous membrane)
  5. Postural orthostatic tachycardia syndrome (abnormal increase in heart rate on becoming upright)
  6. Pruritus (severe itching of the skin)
  7. Rash
  8. Rehabilitation therapy
  9. Renal failure acute (rapid kidney dysfunction)
  10. Rib fracture

male:

  1. Abdominal adhesions (inflammation of abdomen)
  2. Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
  3. Attention deficit/hyperactivity disorder
  4. Autonomic failure syndrome (a degenerative disease of the autonomic nervous system)
  5. Autonomic neuropathy (malfunction of the autonomic nervous system (ans))
  6. Blood glucose fluctuation
  7. Cardiolipin antibody positive
  8. Cerebellar ataxia (loss of coordination)
  9. Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
  10. Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)

What are the common drug interactions of Vaniqa and B12, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

  1. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  2. Cystitis (inflammation of the wall of the bladder)
  3. Fall
  4. Hypoglycaemia (deficiency of glucose in the bloodstream)
  5. Kidney infection
  6. Pertussis (whooping cough: a disease of the respiratory mucous membrane)
  7. Pneumonia
  8. Postural orthostatic tachycardia syndrome (abnormal increase in heart rate on becoming upright)
  9. Rehabilitation therapy
  10. Rib fracture

60+:

  1. Rash
  2. Renal failure (kidney dysfunction)
  3. Arthritis (form of joint disorder that involves inflammation of one or more joints)
  4. Asthenia (weakness)
  5. Asthma
  6. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
  7. Attention deficit/hyperactivity disorder
  8. Autonomic failure syndrome (a degenerative disease of the autonomic nervous system)
  9. Autonomic neuropathy (malfunction of the autonomic nervous system (ans))
  10. Blood glucose fluctuation

What are the existing conditions these people have? *

  1. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 33.33%
  2. Immunodeficiency Common Variable: 5 people, 27.78%
  3. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 16.67%
  4. Hair Growth Abnormal: 2 people, 11.11%
  5. Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 1 person, 5.56%
  6. High Blood Pressure: 1 person, 5.56%
  7. Anaesthesia: 1 person, 5.56%
  8. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 5.56%
  9. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 5.56%
  10. Heart Palpitations (feelings or sensations that your heart is pounding or racing): 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Vaniqa and B12?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Vaniqa and B12:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Vaniqa:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of B12:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Vaniqa and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between B12 and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on eflornithine hydrochloride and cobalamin (the active ingredients of Vaniqa and B12, respectively), and Vaniqa and B12 (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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