Vasotec and Hydramine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vasotec (enalapril maleate) and Hydramine (diphenhydramine hydrochloride). Common drug interactions include atelectasis among females and gastrointestinal haemorrhage among males.

The phase IV clinical study analyzes what interactions people have when they take Vasotec and Hydramine. It is created by eHealthMe based on reports of 33 people who take the same drugs from the FDA, and is updated regularly.

What is Vasotec?

Vasotec has active ingredients of enalapril maleate. It is often used in high blood pressure. eHealthMe is studying from 14,646 Vasotec users. Check the latest studies of Vasotec.

What is Hydramine?

Hydramine has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 114,900 Hydramine users. Check the latest studies of Hydramine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

33 people who take Vasotec and Hydramine together, and have interactions are studied.

Vasotec and Hydramine drug interactions.

What are the common drug interactions of Vasotec and Hydramine, by gender? *:

female:

Atelectasis (partial or complete collapse of the lung)
Azotaemia (excess of urea or other nitrogenous compounds in the blood)
Blood pressure systolic increased
Blood urine present
Bone pain
Bradycardia (abnormally slow heart action)
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Cachexia (loss of weight)
Cardiac failure congestive
Cardiogenic shock (inadequate circulation of blood)

male:

Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Pneumonia
Haemolysis (breaking open of red blood cells and the release of haemoglobin into the surrounding fluid)
Hepatic failure (liver failure)
Liver disorder (liver diseases)
Pulmonary hypertension (increase in blood pressure in the lung artery)
Renal failure acute (rapid kidney dysfunction)
Septic shock (shock due to blood infection)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)

What are the common drug interactions of Vasotec and Hydramine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Bezoar (mass found trapped in the gastrointestinal system)
Gastrointestinal obstruction
Intestinal obstruction
Vomiting

20-29:

Cholecystitis (infection of gallbladder)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Thrombophlebitis (swelling (inflammation) of a vein caused by a blood clot)

30-39:

n/a

40-49:

Abdominal pain
Chest pain
Fatigue (feeling of tiredness)
Headache (pain in head)
Hyperhidrosis (abnormally increased sweating)
Hypotension (abnormally low blood pressure)
Nausea (feeling of having an urge to vomit)
Vomiting
Anaphylactic reaction (serious allergic reaction)
Coma (state of unconsciousness lasting more than six hours)

50-59:

Benign prostatic hyperplasia (benign enlargement of the prostate)
Blood urine present
Bone pain
Bradycardia (abnormally slow heart action)
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Cachexia (loss of weight)
Cerebral artery thrombosis (clot formation in brain blood vessels)
Chest pain
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Dehydration (dryness resulting from the removal of water)

60+:

Sepsis (a severe blood infection that can lead to organ failure and death)
Dehydration (dryness resulting from the removal of water)
Blood pressure systolic increased
Cardiogenic shock (inadequate circulation of blood)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Coma (state of unconsciousness lasting more than six hours)
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Depressed level of consciousness
Ecchymosis (a discoloration of the skin resulting from bleeding underneath)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 12.12%
Pain: 2 people, 6.06%
Itching: 2 people, 6.06%
Irritable Bowel Syndrome: 2 people, 6.06%
Immunodeficiency Common Variable: 2 people, 6.06%
Headache (pain in head): 2 people, 6.06%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 6.06%
Gastric Ulcer (stomach ulcer): 2 people, 6.06%
Fabry's Disease (build up of a particular type of fat, called globotriaosylceramide, in the body's cells): 2 people, 6.06%

* Approximation only. Some reports may have incomplete information.

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