Versed and Elavil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Versed (midazolam hydrochloride) and Elavil (amitriptyline hydrochloride). Common drug interactions include stomatitis among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Versed and Elavil. It is created by eHealthMe based on reports of 64 people who take the same drugs from the FDA, and is updated regularly.

What is Versed?

Versed has active ingredients of midazolam hydrochloride. It is often used in sedation during medical procedure. eHealthMe is studying from 6,869 Versed users. Check the latest studies of Versed.

What is Elavil?

Elavil has active ingredients of amitriptyline hydrochloride. It is often used in depression. eHealthMe is studying from 20,724 Elavil users. Check the latest studies of Elavil.

On Jul, 10, 2026

64 people who take Versed and Elavil together, and have interactions are studied.

What are the common drug interactions of Versed and Elavil, by gender? *:

female:

Stomatitis (inflammation of mucous membrane of mouth)
Abdominal sepsis (abdominal infection)
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Asthenia (weakness)
Bone disorder
Breath odour
Cachexia (loss of weight)

male:

Anxiety
Pain
Loss of consciousness
Renal impairment (severely reduced kidney function)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Coronary artery stenosis (narrowing of coronary artery)
Fatigue (feeling of tiredness)
Hypertensive heart disease
Multi-organ failure (multisystem organ failure)
Pulse absent

What are the common drug interactions of Versed and Elavil, by age (0-1 to 60+)? *:

0-1:

Agitation (state of anxiety or nervous excitement)
Bronchiolitis (inflammation of the membranes lining the bronchioles in lungs)
Enterovirus infection
Influenza
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Respiratory distress (difficulty in breathing)
Rhinovirus infection
Urinary tract infection

2-9:

n/a

10-19:

Wound secretion
Abdominal distension
Abnormal behaviour
Acute respiratory failure
Clonus (series of involuntary, rhythmic, muscular contractions and relaxations)
Constipation
Cough
Depressed level of consciousness
Discomfort
Ear infection

20-29:

n/a

30-39:

Abdominal pain
Confusional state
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Nausea (feeling of having an urge to vomit)
Right ventricular failure (right half of the heart fails to work)
Septic shock (shock due to blood infection)
Skin wound
Somnolence (a state of near-sleep, a strong desire for sleep)
Vomiting

40-49:

Abdominal pain upper
Appetite decreased (decreased appetite occurs when you have a reduced desire to eat)
Back pain
Blood potassium increased
Blood pressure decreased
Bradycardia (abnormally slow heart action)
Cardiac arrest
Confusion
Dyskinesia (abnormality or impairment of voluntary movement)
Fatigue (feeling of tiredness)

50-59:

Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Pseudomembranous colitis (antibiotic-associated diarrhoea (aad), is an infection of the colon)
Purulent discharge (discharge that contains pus)
Pyrexia (fever)
Skin infection
Spinal osteoarthritis (joint cartilage loss in spine)
Swelling
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Weight decreased
Wound infection staphylococcal

60+:

Anxiety
Fear
Cardiac failure congestive
Coronary artery stenosis (narrowing of coronary artery)
Death
Hypertensive heart disease
Multi-organ failure (multisystem organ failure)
Pulse absent
Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)
Stress

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 9.38%
Pain: 5 people, 7.81%
High Blood Pressure: 5 people, 7.81%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 4 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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