Vfend and Purinethol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vfend (voriconazole) and Purinethol (mercaptopurine). Common drug interactions include cholestasis among females and cardio-respiratory arrest among males.

The phase IV clinical study analyzes what interactions people have when they take Vfend and Purinethol. It is created by eHealthMe based on reports of 31 people who take the same drugs from the FDA, and is updated regularly.

What is Vfend?

Vfend has active ingredients of voriconazole. It is often used in aspergillosis. eHealthMe is studying from 12,128 Vfend users. Check the latest studies of Vfend.

What is Purinethol?

Purinethol has active ingredients of mercaptopurine. It is often used in ulcerative colitis. eHealthMe is studying from 3,810 Purinethol users. Check the latest studies of Purinethol.

On Jul, 12, 2026

31 people who take Vfend and Purinethol together, and have interactions are studied.

What are the common drug interactions of Vfend and Purinethol, by gender? *:

female:

Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Drug ineffective
Pruritus generalised (generalized itching)
Rash generalised (rash on most of body parts)
Rash morbilliform (a rash that looks like measles)
Hepatitis acute
Hepatocellular injury (liver injury)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)

male:

Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Cerebellar syndrome (impaired blood circulation to cerebellum due to lesion in artery)
Confusional state
Liver disorder (liver diseases)
Tachypnoea (a condition of rapid breathing over 20 per minute)
Arrhythmia (irregular heartbeat)
Blast cell count increased
Pyrexia (fever)
Bronchial haemorrhage (bleeding in bronchia)
Dyspnoea (difficult or laboured respiration)

What are the common drug interactions of Vfend and Purinethol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Fluoride increased
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Drug ineffective
Pruritus generalised (generalized itching)
Rash generalised (rash on most of body parts)
Rash morbilliform (a rash that looks like measles)
Anxiety
Clonus (series of involuntary, rhythmic, muscular contractions and relaxations)
Headache (pain in head)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)

10-19:

Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Cerebellar syndrome (impaired blood circulation to cerebellum due to lesion in artery)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Bronchopulmonary aspergillosis (lung disorder caused by aspergillus fungi)
Coma (state of unconsciousness lasting more than six hours)
Eye movement disorder
Mydriasis (a dilation of the pupil)
Sinus bradycardia (an unusually slow heartbeat due to heart disease)
Ventricular fibrillation (abnormally irregular heart rhythm)
Lymphadenitis (inflammation or enlargement of a lymph node)

20-29:

Anuria (failure of the kidneys to produce urine)
Hepatitis fulminant (life-threatening condition defined by significantly impaired liver function)
Rales (an abnormal respiratory sound characterized by fine crackles)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Agitation (state of anxiety or nervous excitement)
Alanine aminotransferase increased
Antithrombin iii decreased
Ascites (accumulation of fluid in the abdominal cavity)
Aspartate aminotransferase increased
Asterixis (flapping tremor, or liver flap)

30-39:

n/a

40-49:

n/a

50-59:

Graft versus host disease in skin (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the skin)
Neoplasm progression (growth of tumour)
Acute lymphocytic leukaemia recurrent (cancer in which the bone marrow makes too many lymphocytes-recurrent)
Aplasia (defective development or congenital absence of an organ or tissue)
Death
Febrile neutropenia (fever with reduced white blood cells)

60+:

Thrombocytopenia (decrease of platelets in blood)
Aplasia (defective development or congenital absence of an organ or tissue)
Hepatitis acute
Hepatocellular injury (liver injury)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Platelet count decreased

What are the existing conditions these people have? *

Bronchopulmonary Aspergillosis (lung disorder caused by aspergillus fungi): 14 people, 45.16%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 11 people, 35.48%
Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 8 people, 25.81%
Fever: 7 people, 22.58%
Pulmonary Mycosis (lung infection caused by yeast-like fungi): 2 people, 6.45%
Febrile Bone Marrow Aplasia (bone marrow greatly decreases or stops production of blood cells): 2 people, 6.45%
Cerebral Aspergillosis (pus collection with swelling in brain): 2 people, 6.45%
Caecitis (inflammation of the cecum): 2 people, 6.45%
Bone Marrow Failure: 2 people, 6.45%

* Approximation only. Some reports may have incomplete information.

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