Vfend and Valacyclovir hydrochloride drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vfend (voriconazole) and Valacyclovir hydrochloride (valacyclovir hydrochloride). Common drug interactions include death among females and photosensitivity reaction among males.

The phase IV clinical study analyzes what interactions people have when they take Vfend and Valacyclovir hydrochloride. It is created by eHealthMe based on reports of 68 people who take the same drugs from the FDA, and is updated regularly.

What is Vfend?

Vfend has active ingredients of voriconazole. It is often used in aspergillosis. eHealthMe is studying from 12,128 Vfend users. Check the latest studies of Vfend.

What is Valacyclovir hydrochloride?

Valacyclovir hydrochloride has active ingredients of valacyclovir hydrochloride. It is often used in herpes zoster. eHealthMe is studying from 12,929 Valacyclovir hydrochloride users. Check the latest studies of Valacyclovir hydrochloride.

On Aug, 12, 2026

68 people who take Vfend and Valacyclovir hydrochloride together, and have interactions are studied.

Vfend and Valacyclovir hydrochloride drug interactions.

What are the common drug interactions of Vfend and Valacyclovir Hydrochloride, by gender? *:

female:

Death
Decreased appetite
Delirium (wild excitement)
Escherichia infection (bacterial infection by escherichia coli)
Fusarium infection (fungal infection)
Gastric disorder (disease of stomach)
Gastrointestinal inflammation (inflammation of stomach and intestine)
Hallucination, visual (seeing things that aren't there)
Hot flush (sudden feelings of heat)
Hypophagia (reduced food intake)

male:

Photosensitivity reaction
Thrombocytopenia (decrease of platelets in blood)
Drug ineffective
Embolism (obstruction of an artery, typically by a clot of blood or an air bubble)
Haemorrhage (bleeding)
Infection
Venoocclusive disease (small veins in the liver are obstructed)
Actinic keratosis (skin disease due to sun exposure)
Anaemia (lack of blood)
Chronic lymphocytic leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell))

What are the common drug interactions of Vfend and Valacyclovir Hydrochloride, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Photosensitivity reaction
Toxic optic neuropathy (optic nerve damage caused by toxic (harmful) substances)
Acute lymphocytic leukaemia (cancer of the white blood cells)
Aplasia (defective development or congenital absence of an organ or tissue)
Drug ineffective
Embolism (obstruction of an artery, typically by a clot of blood or an air bubble)
Haemorrhage (bleeding)
Infection
Venoocclusive disease (small veins in the liver are obstructed)
Acute lymphocytic leukaemia recurrent (cancer in which the bone marrow makes too many lymphocytes-recurrent)

30-39:

Neutropenic colitis (inflammation of the cecum, often with involvement of the ascending colon and ileum, a life threatening condition)
Sepsis (a severe blood infection that can lead to organ failure and death)
Respiratory failure (inadequate gas exchange by the respiratory system)
Ileus (a painful obstruction of the ileum or other part of the intestine)
Meningitis aseptic (a condition that causes the membranes covering your brain and spinal cord to become inflamed)

40-49:

Acute graft versus host disease in skin (acute complication on skin following an allogeneic tissue/blood transplant)
Acute pulmonary oedema (sudden deposit of fluid in the lung))
Aggression
Agitation (state of anxiety or nervous excitement)
Altered state of consciousness (altered state of mind)
Anaemia (lack of blood)
Blood lactate dehydrogenase increased
Confusional state
Encephalopathy (functioning of the brain is affected by some agent or condition)
Lung disorder (lung disease)

50-59:

Thrombocytopenia (decrease of platelets in blood)
Posterior reversible encephalopathy syndrome (posterior reversible encephalopathy syndrome (pres), also known as reversible posterior leukoencephalopathy syndrome (rpls), is a syndrome characterized by headache, confusion, seizures and visual loss)
Pruritus (severe itching of the skin)
Chronic lymphocytic leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell))
Richter's syndrome (hairy cell cancer changes in fast growing b cell cancer tumour)
Staphylococcal infection (an infection with staphylococcus bacteria)
Abdominal pain
Anaemia (lack of blood)
Asthenia (weakness)
Death

60+:

Actinic keratosis (skin disease due to sun exposure)
Coma (state of unconsciousness lasting more than six hours)
Blood creatinine increased
Bronchopulmonary aspergillosis (lung disorder caused by aspergillus fungi)
Constipation
Device related infection
Folliculitis (infection of hair root)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Oral candidiasis (fungal infection of mouth)
Oral herpes (viral infection of mouth)

What are the existing conditions these people have? *

Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 17 people, 25.00%
Anaemia (lack of blood): 9 people, 13.24%
Immunodeficiency Disorders: 8 people, 11.76%
Infection: 7 people, 10.29%
Fever: 7 people, 10.29%
Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 6 people, 8.82%
High Blood Pressure: 5 people, 7.35%
Bronchopulmonary Aspergillosis (lung disorder caused by aspergillus fungi): 5 people, 7.35%
Venoocclusive Liver Disease (small veins in the liver are obstructed): 4 people, 5.88%
Stress And Anxiety: 4 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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