Viagra and Efudex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Viagra (sildenafil citrate) and Efudex (fluorouracil). Common drug interactions include cough among males.

The phase IV clinical study analyzes what interactions people have when they take Viagra and Efudex. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Viagra?

Viagra has active ingredients of sildenafil citrate. It is often used in erection problems. eHealthMe is studying from 63,865 Viagra users. Check the latest studies of Viagra.

What is Efudex?

Efudex has active ingredients of fluorouracil. It is often used in actinic keratosis. eHealthMe is studying from 1,391 Efudex users. Check the latest studies of Efudex.

On May, 23, 2026

16 people who take Viagra and Efudex together, and have interactions are studied.

What are the common drug interactions of Viagra and Efudex, by gender? *:

female:

n/a

male:

Cough
Pain
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Asthma
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Benign neoplasm (benign (non-cancerous) tumour)
Bone density decreased
Bone loss
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Constipation

What are the common drug interactions of Viagra and Efudex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Bone density decreased
Bone loss
Emotional distress
Hydronephrosis (water inside the kidney)
Nephrolithiasis (calculi in the kidneys)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Osteonecrosis (death of bone)

50-59:

Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Asthma
Dysphagia (a condition in which swallowing is difficult or painful)
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
Essential hypertension (primary hypertension)
Hypergonadism (hyperfunction of the gonads)
Hypertonic bladder (bladder-storage function that causes a sudden urge to urinate)
Lipodystrophy acquired (a regional loss of subcutaneous adipose tissue which usually starts in the face, extends downward acquired)
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)

60+:

Cough
Abdominal distension
Faeces discoloured
Flatulence (flatus expelled through the anus)
Frequent bowel movements
Haematemesis (vomiting of blood)
Joint swelling
Loss of consciousness
Lower limb fracture
Malignant melanoma stage iv (the cancer has spread to other places in the body, such as the lung, liver, brain, bone, soft tissue, or gastrointestinal (gi) tract. cancer may have spread to places in the skin far away from where it first started)

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 4 people, 25.00%
Prostate Cancer: 2 people, 12.50%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 2 people, 12.50%
Stress And Anxiety: 1 person, 6.25%
Secondary Immunodeficiency (lack of immunity due to some disease): 1 person, 6.25%
Rosacea (a skin condition that causes facial redness): 1 person, 6.25%
Pain: 1 person, 6.25%
Nausea (feeling of having an urge to vomit): 1 person, 6.25%
Hypersensitivity: 1 person, 6.25%
Hiv Infection: 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

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