Viagra and Xgeva drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Viagra (sildenafil citrate) and Xgeva (denosumab). Common drug interactions include brain abscess among females and constipation among males.

The phase IV clinical study analyzes what interactions people have when they take Viagra and Xgeva. It is created by eHealthMe based on reports of 29 people who take the same drugs from the FDA, and is updated regularly.

What is Viagra?

Viagra has active ingredients of sildenafil citrate. It is often used in erection problems. eHealthMe is studying from 63,865 Viagra users. Check the latest studies of Viagra.

What is Xgeva?

Xgeva has active ingredients of denosumab. It is often used in breast cancer. eHealthMe is studying from 37,717 Xgeva users. Check the latest studies of Xgeva.

On Apr, 26, 2026

29 people who take Viagra and Xgeva together, and have interactions are studied.

What are the common drug interactions of Viagra and Xgeva, by gender? *:

female:

Brain abscess
Death
Meningitis (inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)

male:

Constipation
Nausea (feeling of having an urge to vomit)
Metastases to pelvis (cancer spreads to pelvis)
Pathological fracture (broken bone caused by disease)
Ageusia (loss of taste functions of the tongue)
Arrhythmia (irregular heartbeat)
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Asthenia (weakness)
Cardiac failure congestive
Cardiomyopathy (weakening of the heart muscle)

What are the common drug interactions of Viagra and Xgeva, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Brain abscess
Death
Meningitis (inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)

60+:

Constipation
Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Arrhythmia (irregular heartbeat)
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Asthenia (weakness)
Cardiac failure congestive
Cardiomyopathy (weakening of the heart muscle)
Cerebral infarction (less blood supply to brain resulting tissue damage)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Disease progression

What are the existing conditions these people have? *

Prostate Cancer: 9 people, 31.03%
Multiple Myeloma (cancer of the plasma cells): 9 people, 31.03%
Prostate Cancer Metastatic: 4 people, 13.79%
Metastases To Bone (cancer spreads to bone): 4 people, 13.79%
Pain: 3 people, 10.34%
Thyroid Cancer: 2 people, 6.90%
Sleep Disorder: 2 people, 6.90%
Metastases To Lymph Nodes (cancer spreads to lymph node): 2 people, 6.90%
Joint Pain: 2 people, 6.90%

* Approximation only. Some reports may have incomplete information.

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