Zestoretic and Viagra drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zestoretic (hydrochlorothiazide; lisinopril) and Viagra (sildenafil citrate). Common drug interactions include drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Zestoretic and Viagra. It is created by eHealthMe based on reports of 83 people who take the same drugs from the FDA, and is updated regularly.

What is Zestoretic?

Zestoretic has active ingredients of hydrochlorothiazide; lisinopril. It is often used in high blood pressure. eHealthMe is studying from 4,342 Zestoretic users. Check the latest studies of Zestoretic.

What is Viagra?

Viagra has active ingredients of sildenafil citrate. It is often used in erection problems. eHealthMe is studying from 63,865 Viagra users. Check the latest studies of Viagra.

On Jul, 03, 2026

83 people who take Zestoretic and Viagra together, and have interactions are studied.

Zestoretic and Viagra drug interactions.

What are the common drug interactions of Zestoretic and Viagra, by gender? *:

female:

n/a

male:

Drug ineffective
Renal failure acute (rapid kidney dysfunction)
Weight increased
Acute myocardial infarction (acute heart attack)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Arthralgia (joint pain)
Blood glucose increased
Bradycardia (abnormally slow heart action)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)

What are the common drug interactions of Zestoretic and Viagra, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Oedema peripheral (superficial swelling)
Weight increased
Angioplasty
Arterial occlusive disease (slow process through which arteries throughout the body become progressively narrowed and eventually completely blocked)
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Cardiac disorder
Death
Drug effect decreased
Facial pain
Hospitalisation

50-59:

Drug ineffective
Drug toxicity
Haematocrit decreased
Haemoglobin decreased
Hyporeflexia (a condition of below normal or absent reflexes)
Ischaemia (insufficient supply of blood to an organ, usually due to a blocked artery)
Limb discomfort (discomfort in leg)
Muscle injury
Muscle necrosis (muscle cell damage)
Muscle strain (an injury to a muscle in which the muscle fibres tear)

60+:

Drug ineffective
Renal failure acute (rapid kidney dysfunction)
Dyspnoea (difficult or laboured respiration)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Nausea (feeling of having an urge to vomit)
Pain
Chronic kidney disease
Diarrhoea
Lung infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung)
Pyrexia (fever)

What are the existing conditions these people have? *

Type 2 Diabetes: 8 people, 9.64%
High Blood Cholesterol: 8 people, 9.64%
Hyperlipidaemia (presence of excess lipids in the blood): 6 people, 7.23%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 6.02%

* Approximation only. Some reports may have incomplete information.

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