Viberzi and Xifaxan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Viberzi (eluxadoline) and Xifaxan (rifaximin). Common drug interactions include malaise among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Viberzi and Xifaxan. It is created by eHealthMe based on reports of 44 people who take the same drugs from the FDA, and is updated regularly.

What is Viberzi?

Viberzi has active ingredients of eluxadoline. eHealthMe is studying from 3,077 Viberzi users. Check the latest studies of Viberzi.

What is Xifaxan?

Xifaxan has active ingredients of rifaximin. It is often used in irritable bowel syndrome. eHealthMe is studying from 16,609 Xifaxan users. Check the latest studies of Xifaxan.

On Aug, 01, 2026

44 people who take Viberzi and Xifaxan together, and have interactions are studied.

What are the common drug interactions of Viberzi and Xifaxan, by gender? *:

female:

Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Constipation
Abdominal pain
Autoimmune disorder (a condition in which the immune system attacks the body's normal substances and tissue)
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Sinusitis (inflammation of sinus)
Diarrhoea
Asthenia (weakness)
Ear infection

male:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Hepatic steatosis (fatty liver disease)
Hepatosplenomegaly (enlargement of both the liver and the spleen)
Osteopenia (a condition where bone mineral density is lower than normal)
Platelet count decreased
Urinary tract infection
Wrist fracture
Cardiac arrest

What are the common drug interactions of Viberzi and Xifaxan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Colitis (inflammation of colon)
Nausea (feeling of having an urge to vomit)
Viral infection
Malaise (a feeling of general discomfort or uneasiness)
Postural orthostatic tachycardia syndrome (abnormal increase in heart rate on becoming upright)

40-49:

n/a

50-59:

Ear infection
Malaise (a feeling of general discomfort or uneasiness)
Sinusitis (inflammation of sinus)

60+:

Constipation
Pickwickian syndrome (extreme obesity accompanied by sleepiness, hypoventilation, and polycythemia)
Hepatosplenomegaly (enlargement of both the liver and the spleen)
Myasthenia gravis (a chronic condition that causes muscles to tire and weaken easily)
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)
Pain
Platelet count decreased
Renal failure (kidney dysfunction)
Urinary tract infection

What are the existing conditions these people have? *

Primary Myelofibrosis (primary disorder of the bone marrow): 12 people, 27.27%
Polycythaemia Vera (blood disorder in which the bone marrow makes too many red blood cells): 12 people, 27.27%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 15.91%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 13.64%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 11.36%
Diarrhea: 5 people, 11.36%
Indigestion: 4 people, 9.09%
Immunodeficiency Common Variable: 4 people, 9.09%
High Blood Pressure: 4 people, 9.09%
Stress And Anxiety: 3 people, 6.82%

* Approximation only. Some reports may have incomplete information.

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