Vicodin and Activella drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vicodin (acetaminophen; hydrocodone bitartrate) and Activella (estradiol; norethindrone acetate). Common drug interactions include dizziness among females.

The phase IV clinical study analyzes what interactions people have when they take Vicodin and Activella. It is created by eHealthMe based on reports of 39 people who take the same drugs from the FDA, and is updated regularly.

What is Vicodin?

Vicodin has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 63,357 Vicodin users. Check the latest studies of Vicodin.

What is Activella?

Activella has active ingredients of estradiol; norethindrone acetate. It is often used in menopause. eHealthMe is studying from 1,971 Activella users. Check the latest studies of Activella.

On Jul, 19, 2026

39 people who take Vicodin and Activella together, and have interactions are studied.

Vicodin and Activella drug interactions.

What are the common drug interactions of Vicodin and Activella, by gender? *:

female:

Dizziness
Fall
Candidiasis (candidiasis or thrush is a fungal infection)
Congestive cardiomyopathy (weakening of heart muscle)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Cough
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Diplopia (double vision)
Discomfort

male:

n/a

What are the common drug interactions of Vicodin and Activella, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Depression
Urinary tract infection

30-39:

Constipation
Inflammatory bowel disease
Food poisoning (poison in food)
Abdominal pain lower
Nausea (feeling of having an urge to vomit)
Sinus node dysfunction (a group of abnormal heart rhythms)

40-49:

n/a

50-59:

Candidiasis (candidiasis or thrush is a fungal infection)
Congestive cardiomyopathy (weakening of heart muscle)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Cough
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Diplopia (double vision)
Discomfort
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Dizziness

60+:

Breast cancer
Peripheral swelling

What are the existing conditions these people have? *

Neoplasm Malignant (cancer tumour): 12 people, 30.77%
Endometriosis (appearance of endometrial tissue outside the uterus and causing pelvic pain): 8 people, 20.51%
Stress And Anxiety: 8 people, 20.51%
Vitamin D Decreased: 5 people, 12.82%
Dysmenorrhea (painful menstruation): 5 people, 12.82%
Uterine Leiomyoma (uterine benign tumour derived from smooth muscle): 5 people, 12.82%
Muscle Strain (an injury to a muscle in which the muscle fibres tear): 5 people, 12.82%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 12.82%
Anaemia (lack of blood): 5 people, 12.82%
Migraine (headache): 4 people, 10.26%

* Approximation only. Some reports may have incomplete information.

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