Vicodin and Flurbiprofen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vicodin (acetaminophen; hydrocodone bitartrate) and Flurbiprofen (flurbiprofen). Common drug interactions include angiopathy among females and arthralgia among males.

The phase IV clinical study analyzes what interactions people have when they take Vicodin and Flurbiprofen. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Vicodin?

Vicodin has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 63,357 Vicodin users. Check the latest studies of Vicodin.

What is Flurbiprofen?

Flurbiprofen has active ingredients of flurbiprofen. It is often used in rheumatoid arthritis. eHealthMe is studying from 2,677 Flurbiprofen users. Check the latest studies of Flurbiprofen.

On Aug, 01, 2026

15 people who take Vicodin and Flurbiprofen together, and have interactions are studied.

Vicodin and Flurbiprofen drug interactions.

What are the common drug interactions of Vicodin and Flurbiprofen, by gender? *:

female:

Angiopathy (generic term for a disease of the blood vessels)
Complex regional pain syndrome (long lasting pain condition most often affecting one of the limbs (arms, legs, hands, or feet))
Tendon rupture (tear of tendon)
Carpal tunnel decompression
Electrocardiogram qt prolonged
Fatigue (feeling of tiredness)
Anaemia (lack of blood)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Asthenia (weakness)
Chest pain

male:

Arthralgia (joint pain)
Chest pain
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)
Erectile dysfunction
Fatigue (feeling of tiredness)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Intermittent claudication
Loss of consciousness

What are the common drug interactions of Vicodin and Flurbiprofen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Carpal tunnel decompression
Depression
Entrapment neuropathy (direct pressure on a single nerve)
Spinal fusion acquired
Spinal fusion surgery

50-59:

Angiopathy (generic term for a disease of the blood vessels)
Complex regional pain syndrome (long lasting pain condition most often affecting one of the limbs (arms, legs, hands, or feet))
Tendon rupture (tear of tendon)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Arthralgia (joint pain)
Asthenia (weakness)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Cardiac arrest
Cardioactive drug level increased
Chest discomfort

60+:

Electrocardiogram qt prolonged
Fatigue (feeling of tiredness)
Gastric ulcer (stomach ulcer)
Gastritis (inflammation of stomach)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Pulmonary congestion (congestion in the lungs)
Pyrexia (fever)
Upper gastrointestinal haemorrhage (upper gastrointestinal bleeding)
Anaemia (lack of blood)
Arthritis (form of joint disorder that involves inflammation of one or more joints)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 40.00%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 3 people, 20.00%
Nausea (feeling of having an urge to vomit): 3 people, 20.00%
Complex Regional Pain Syndrome (long lasting pain condition most often affecting one of the limbs (arms, legs, hands, or feet)): 3 people, 20.00%
Promotion Of Peripheral Circulation: 2 people, 13.33%
Back Pain: 2 people, 13.33%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 2 people, 13.33%
Inflammation: 2 people, 13.33%
Immobilisation Prolonged (continuing for a long time rest): 2 people, 13.33%
Constipation: 2 people, 13.33%

* Approximation only. Some reports may have incomplete information.

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